Results of the studies with CT scan and MRI in asymptomatic individuals with heterozygous FH
| Study | FH subjects (n) | Controls (n) | Imaging technique | Results |
|---|---|---|---|---|
| ten Kate et al31 | 67 | 30 healthy subjects | CTCA | Patients with FH had greater coronary calcium score. |
| Viladés Medel et al32 | 50 | 70 healthy subjects | CTCA | Patients with FH had a greater prevalence, extension and severity of subclinical CHD. |
| Ten Kate et al33 | 59 patients with FH with null mutation | 86 patients with FH with reduced or normal LDLR function | CTCA | LDLR-negative patients had higher number of diseased coronary artery segments per patient. |
| Neefjes et al34 | 140 patients with FH with follow-up scans | – | CTCA | About 54% of all coronary plaques were calcified. |
| Neefjes et al35 | 101 | 126 patients without FH having non-angina chest pain | CTCA | Total calcium score was significantly higher in patients with FH. |
| Miname et al36 | 102 | 35 healthy subjects | CTCA | Patients with FH had a significantly higher number of plaques, stenosis, segments with plaques and calcium scores. |
| Martinez et al37 | 89 | 31 healthy subjects | 16 or 64 sliced CT | Coronary artery calcification prevalence and severity were higher in FH. |
| Ye et al38 | 32 | 34 healthy subjects | Electron-beam CT | Coronary artery calcification was higher in FH. |
| Caballero et al39 | 36 | 19 healthy subjects | MRI of aorta | Atherosclerotic plaques in descending aorta were significantly higher in FH cases. |
| Soljanlahti et al40 | 39 | 25 healthy subjects | MRI of aorta | No difference in any of the morphological or functional aortic parameters between patients and controls detected. |
| Schmitz et al41 | 11 | 26 subjects | MRI of aorta | The descending thoracic aorta wall area was significantly larger in patients with FH. |
CHD, coronary heart disease; CTCA, CT coronary angiography; FH, familial hypercholesterolaemia; LDLR, LDL-receptor gene.