The OR for coronary heart disease (CHD) by mutation type adjusted for risk factors (table from Humphries et al10)
| Mutation | Patients with CHD (n) | Patients without CHD (n) | OR (95% CI)* |
|---|---|---|---|
| None | 55 | 101 | 1 |
| LDLR | 91 | 145 | 1.84 (1.10 to 3.06), p=0.02 |
| APOB | 6 | 4 | 3.40 (0.71 to 16.36), p=0.13 |
| PCSK9 | 6 | 1 | 19.96 (1.88 to 211.55), p=0.01 |
*OR for having CHD adjusted for age, sex, smoking and systolic blood pressure at recruitment compared with the patients where no mutation was identified.
APOB, apolipoprotein B; CHD, coronary heart disease; LDLR, LDL-receptor gene; PCSK9, protein convertase subtilisin/kexin 9.