Table 2

General linear model showing independent predictors of log-transformed TMAO levels, with coefficients reported for 2000 bootstrapped samples

	Standardised coefficient	Unstandardised coefficient	SE	Lower CI	Upper CI	p Value
Age	0.125	0.004	0.001	0.002	0.006	<0.0005
Urea	0.318	0.018	0.002	0.014	0.022	<0.0005
eGFR	−0.220	−0.004	0.001	−0.005	−0.003	<0.0005
PH diabetes	0.074	0.057	0.023	0.013	0.102	0.009
Current smoker	0.084	0.101	0.039	0.026	0.179	0.009
Atrial fibrillation	0.066	0.048	0.022	0.005	0.091	0.028
NYHA class	−0.061	−0.037	0.018	−0.072	0.001	0.050
Male sex	0.015	0.011	0.025	−0.034	0.058	NS
PH heart failure	0.033	0.026	0.023	−0.190	0.072	NS
PH IHD	0.009	0.007	0.024	−0.041	0.053	NS
Heart rate	−0.017	0.000	0.000	−0.001	0.001	NS
Systolic BP	−0.001	−1.09×10⁻⁵	0.000	−0.001	0.001	NS
Log NT-proBNP	0.020	0.013	0.020	−0.026	0.052	NS
Haemoglobin	−0.022	0.000	0.001	−0.002	0.001	NS
Pulmonary oedema	0.011	0.008	0.025	−0.040	0.059	NS
Orthopnoea	0.008	0.006	0.023	−0.037	0.051	NS
Oedema	0.047	0.036	0.026	−0.014	0.087	NS
Raised JVP	−0.022	−0.016	0.023	−0.062	0.026	NS
PH COPD	0.045	0.056	0.040	−0.019	0.140	NS
PH hypertension	−0.027	−0.020	0.023	−0.064	0.026	NS

Lower and upper CIs refer to 95% CIs.
BP, blood pressure; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; IHD, ischaemic heart disease; JVP, jugular venous pressure; NT-proBNP, N-terminal pro B-type natriuretic peptide; NYHA, New York Heart Association; PH, past history; TMAO, trimethylamine N-oxide.