Burden of variants in DCM genes in familial and non-familial DCM
| Gene | Percentage of variants in familial DCM patients (N=95) (=total number of variants in cohort) | Percentage of variants in non familial DCM patients (N=500) (=total number of variants in cohort) | P value |
|---|---|---|---|
| Titin (TTN) | 22.1% (21) | 7.6% (38) | <0.001 |
| Lamin A/C (LMNA) | 6.3% (6) | 1.2% (6) | 0.006 |
| Myosin heavy chain beta (MYH7) | 6.3% (6) | 4.2% (21) | 0.42 |
| Plakophilin 2 (PKP2) | 4.2% (4) | 4.0% (20) | 1.0 |
| Troponin T 2 (TNNT2) | 3.2% (3) | 1.2% (6) | 0.16 |
| RNA Binding Motif Protein 20 (RBM20) | 2.1% (2) | 4.4% (22) | 0.40 |
| Tropomyosin1 (TPM1) | 1.1% (1) | 0 | 0.16 |
| BCL2-Associated Athanogene 3 (BAG3) | 1.1% (1) | 1.6% (8) | 1 |