Characteristics of participants in the seven studies
| BRHS | BWHHS | CaPS | EAS | ELSA | NSHD | WHII | Total | |
|---|---|---|---|---|---|---|---|---|
| Total | 2138 | 1631 | 1121 | 632 | 1184 | 2330 | 2815 | 11 851 |
| Follow-up (years) | 10 | 10 | 10 | 10 | ∼5 | 10 | 10 | |
| CVD events during follow-up (n) | 205 | 268 | 119 | 235 | 142 | 109 | 366 | 1444 |
| 10-year CVD event rate (per 100 person-years) | 8.4* | 11.4* | 14.7 | 37.2 | 20.8*† | 4.7 | 15.2 | 13.6 |
| Predicted 10-year CVD risk (QRISK-2) (per 100 person-years) | 8.4 | 26.7 | 18.1 | 20.6 | 30.2 | 10.7 | 8.2 | 15.1 |
| Age (years) | 48.9 (5.6) | 70.7 (5.3) | 56.7 (4.4) | 64.2 (5.7) | 71.5 (8.5) | 53.0 (0.0) | 48.8 (6.0) | |
| Sex, % male | 100 | 0 | 100 | 46.4 | 51.9 | 49.4 | 77.2 | |
| Ever smokers (%) | 33.1 | 46.0 | 80.5 | 22.6 | 64.1 | 72.5 | 48.3 | |
| Family history of CVD (%) | – | 58.2 | – | 67.6 | 5.3 | 63.0 | 51.6 | |
| Townsend score | 0.355 (3.21) | −0.21 (0.91) | ||||||
| Body mass index (kg/m2) | 25.4 (2.9) | 27.4 (4.8) | 26.5 (3.6) | 25.2 (3.6) | 27.3 (4.2) | 27.2 (4.5) | 25.1 (3.5) | |
| Total cholesterol (mmol/L) | 6.36 (1.04) | 6.79 (1.21) | 5.61 (0.98) | 7.08 (1.32) | 6.12 (1.21) | 6.12 (1.05) | 6.44 (1.16) | |
| Systolic blood pressure (mm Hg) | 144.1 (20.2) | 154.0 (27.0) | 146.0 (22.3) | 144.6 (25.1) | 144.6 (19.6) | 137.7 (21.1) | 121.3 (14.0) | |
| Treated hypertension (%) | 2.2 | 28.6 | – | 16.8 | 36.0 | 11.6 | 5.8 | |
| Calendar years for baseline data collection | 1978–1980 | 1999–2001 | 1984–1988 | 1987–1988 | 2004–2005 | 1999 | 1992–1993 |
Mean (SD) tabulated for continuous variables, percentage for binary variables.
*Adjusted for nested case-control study design, accounting for sampling fraction of controls.
†In ELSA, follow-up was for 5 years so the observed number of events was doubled for the 10-year rate.
CVD, cardiovascular disease.