Net reclassification index (NRI) based on addition of gene score to QRISK, calculated using 10% risk cut-off
| No. of people | |||||
|---|---|---|---|---|---|
| QRISK+externally weighted gene score NO CVD (n=15928.64*) | Reclassified | ||||
| Predicted risk QRISK | <10 | ≥10 | Increased risk | Decreased risk | Net correctly reclassified |
| <10 ≥10 | 5475.02 1156.07 | 785.56 8511.99 | 785.56 | 1156.07 | 2.33% (1.8 to 2.9) |
| QRISK+externally weighted gene score CVD (N=1697.81*) | |||||
| Predicted risk QRISK | <10 | ≥10 | |||
| <10 ≥10 | 352.27 100.58 | 65.36 1179.60 | 65.36 | 100.58 | −2.07 (−3.56 to −0.59) |
| NRI (95% CI)† NRI (95% CI)‡ | 0.25% (−1.33 to 1.83) p=0.76 1.18% (−0.23 to 2.60) p=0.10 | ||||
*Numbers inflated due to extra weighting assigned to three studies where samples of controls were taken (see statistical analysis section).
†No adjustment for study.
‡Results from meta-analysis of individual study results (fixed effects).
CVD, cardiovascular disease.