Quality of life (QOL) scores and respiratory functional parameters at baseline and 12 weeks
| Non-CR group (n=24) | CR group (n=17) | Between-group p value | |||||
|---|---|---|---|---|---|---|---|
| Baseline | 12 weeks | Within-group p value | Baseline | 12 weeks | Within-group p value | ||
| QOL questionnaire SF-36* | n=24 | n=24 | n=15 | n=15 | |||
| Physical functioning | 75 (54–90) | 80 (61–94) | 0.11# | 75 (50–85) | 85 (65–94) | 0.17# | 0.68## |
| Role-physical | 78 (53–94) | 81 (50–100) | 0.96# | 69 (44–94) | 69 (38–100) | 1.00# | 0.94## |
| Bodily pain | 100 (62–100) | 79 (65–100) | 0.21# | 100 (80–100) | 100 (62–100) | 0.55# | 0.91## |
| General health perception | 62 (37–67) | 56 (38–72) | 0.48# | 52 (35–77) | 62 (52–72) | 0.37# | 0.37## |
| Vitality | 75 (56–92) | 63 (50–81) | 0.11# | 75 (50–81) | 75 (50–88) | 0.87# | 0.21## |
| Social functioning | 88 (66–97) | 88 (75–100) | 0.17# | 63 (50–100) | 63 (50–100) | 0.46# | 0.52## |
| Role-emotional | 83 (50–100) | 88 (75–100) | 0.13# | 100 (67–100) | 100 (75–100) | 0.66# | 0.99## |
| Mental health | 80 (58–85) | 75 (60–85) | 0.57# | 80 (55–95) | 90 (60–100) | 0.10# | 0.09## |
| Depression questionnaire† | n=22 | n=22 | n=15 | n=15 | |||
| PHQ-9 | 3.5 (1.0–7.5) | 5.0 (1.8–8.3) | 0.20# | 1.0 (0.0–4.0) | 2.0 (0.0–5.0) | 0.93# | 0.20## |
| Respiratory function‡ | n=24 | n=24 | n=14 | n=14 | |||
| VC % predicted (%) | 103±11 | 103±12 | 0.96 | 117±13 | 117±14 | 1.00 | 0.46 |
| FEV1.0% predicted (%) | 97±15 | 93±20 | 0.09 | 112±16 | 112±17 | 0.85 | 0.41 |
| DLCO % predicted (%) | 72±13 | 75±11 | 0.09 | 71±12 | 75±16 | 0.04 | 0.69 |
| Arterial blood gas analysis§ | n=22 | n=22 | n=17 | n=17 | |||
| PaO2 (mm Hg) | 65.6±9.8 | 65.0±10.2 | 0.85 | 67.3±8.8 | 65.9±9.7 | 0.58 | 0.90 |
| PaCO2 (mm Hg) | 39.5±4.4 | 39.3±3.4 | 0.79 | 38.0±3.8 | 39.8±3.3 | 0.07 | 0.27 |
| AaDO2 (mm Hg) | 34.8±9.1 | 35.6±8.0 | 0.75 | 34.9±9.9 | 34.0±11.3 | 0.68 | 0.58 |
Results are expressed as mean±SD or median (25% and 75% centile). Within-group p values from #Wilcoxon signed-rank tests or otherwise paired t tests. Between-group p values from ##the Mann–Whitney U test comparing the changes from baseline or otherwise ANCOVA.
*15 patients in the CR group for this data point, because we could not obtain data for 2 patients.
†22 patients in the non-CR group and 15 patients in the CR group for this data point, because we could not obtain data for 4 patients.
‡14 patients in the CR group for this data point, because we could not obtain data on preinterventional respiratory function for 3 patients.
§22 patients in the non-CR group for this data point, because we could not obtain completely reliable data for 2 patients.
AaDO2, alveolar-arterial PO2 difference; CR, cardiac rehabilitation; DLCO, diffusing capacity of the lung for carbon monoxide; FEV1, forced expiratory volume in 1 s; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension; PHQ-9, Patient Health Questionnaire-9; SF-36, Short Form Health Survey; VC, vital capacity.