Variable | Cohort 1 2010–2011 (n=5500) | Cohort 2 2011–2013 (n=11 662) | Cohort 3 2013–2014 (n=11 462) | Cohort 4 2014–2015 (n=11 046) |
---|---|---|---|---|
Female, n/N (%) | 2402/5500 (43.7) | 5116/11 662 (43.9) | 5191/11 462 (45.3) | 4870/11 046 (44.1) |
Age at diagnosis, years, mean (SD) | 69.8 (11.5) | 69.8 (11.4) | 69.6 (11.4)a | 69.6 (11.7) |
Ethnicity, n/N (%) | ||||
Caucasian/Hispanic/Latino | 3691/5500 (67.1) | 8647/11 662 (74.1) | 7896/11 462 (68.9) | 7050/11 046 (63.8) |
Asian | 1589/5500 (28.8) | 2392/11 662 (20.5) | 3175/11 462 (27.7) | 3574/11 046 (32.4) |
Other | 68/5500 (1.2) | 244/11 662 (2.1) | 147/11 462 (1.3) | 239/11 046 (2.2) |
Unwilling to declare | 152/5500 (2.8) | 379/11 662 (3.2) | 244/11 462 (2.1) | 183/11 046 (1.7) |
Medical history, n/N (%) | ||||
CHF | 1026/5498 (18.7) | 2506/11 662 (21.5) | 2206/11 462 (19.2) | 2128/11 046 (19.3) |
CAD | 1059/5498 (19.3) | 2357/11 662 (20.2) | 2495/11 462 (21.8) | 2428/11 046 (22.0) |
ACS | 553/5498 (10.1) | 1061/11 659 (9.1) | 1258/11 257 (11.2) | 1281/10 884 (11.8) |
Vascular disease | 847/5498 (15.4) | 1653/11 662 (14.2) | 1828/11 462 (15.9) | 1789/11 046 (16.2) |
Systemic embolism | 35/5498 (0.6) | 74/11 652 (0.6) | 85/11 383 (0.7) | 78/10 981 (0.7) |
Stroke/TIA | 727/5498 (13.2) | 1459/11 662 (12.5) | 1236/11 462 (10.8) | 1219/11 046 (11.0) |
Bleeding | 172/5498 (3.1) | 325/11 651 (2.8) | 283/11 400 (2.5) | 262/10 995 (2.4) |
History of hypertension | 4224/5498 (76.8) | 9172/11 662 (78.6) | 8761/11 419 (76.7) | 8224/11 004 (74.7) |
Diabetes mellitus | 1215/5498 (22.1) | 2535/11 662 (21.7) | 2457/11 462 (21.4) | 2443/11 046 (22.1) |
Moderate-to-severe CKD* | 495/5497 (9.0) | 1265/11 662 (10.8) | 1209/11 462 (10.5) | 1104/11 045 (10.0) |
Risk scores | ||||
CHA2DS2-VASc, median (Q1–Q3) | 3 (2–4)b | 3 (2–4)c | 3 (2–4)d | 3 (2–4)e |
CHA2DS2-VASc, 0–1, n/N (%) | 815/5406 (15.1) | 1531/11 293 (13.6) | 1666/11 252 (14.8) | 1700/10 830 (15.7) |
HAS-BLED, median (Q1–Q3)† | 1 (1–2)f | 1 (1–2)g | 1 (1–2)h | 1 (1–2)i |
HAS-BLED, 0–2, n/N (%)† | 3109/3561 (87.3) | 6321/7302 (86.6) | 7650/8584 (89.1) | 7824/8654 (90.4) |
a1 patient missing; b94 patients missing; c369 patients missing; d210 patients missing; e216 patients missing; f1939 patients missing; g4360 patients missing; h2878 patients missing; i2392 patients missing.
ACS, acute coronary syndrome; CAD, coronary artery disease; CHA2DS2-VASc, cardiac failure, hypertension, age ≥75 (doubled), diabetes, stroke (doubled)-vascular disease, age 65–74 and sex category (female); CHF, congestive heart failure; CKD, chronic kidney disease; NKF KDOQI, National Kidney Foundation's Kidney Disease Outcomes Quality Initiative; TIA, transient ischaemic attack.
*Includes NKF KDOQI stages III–V.
†‘modified’ HAS-BLED, hypertension, abnormal renal/liver function (1 point each), stroke, bleeding history or predisposition, elderly (>65), drugs/alcohol concomitantly (1 point each).