Net reclassification index (NRI) based on addition of gene score to QRISK, calculated using 20% risk cut-off
| No. of people | |||||
|---|---|---|---|---|---|
| QRISK+externally weighted gene score NO CVD (N=15928.64*) | Reclassified | ||||
| Predicted risk QRISK | <20 | ≥20 | Increased risk | Decreased risk | Net correctly reclassified |
| <20 ≥20 | 9789.24 927.36 | 783.85 4428.19 | 783.85 | 927.36 | 0.90% (0.39 to 1.41) |
| QRISK+externally weighted gene score CVD (N=1707.7*) | |||||
| Predicted risk QRISK | <20 | ≥20 | |||
| <20 ≥20 | 605.5 124.3 | 146.1 831.9 | 146.1 | 124.3 | −0.25% (−2.09 to 1.58) |
| NRI (95% CI)† NRI (95% CI)‡ | 0.65% (−1.26 to 2.55) p=0.51 0.68% (−1.16 to 2.52) p=0.47 | ||||
*Numbers inflated due to extra weighting assigned to three studies where samples of controls were taken (see statistical analysis section).
†No adjustment for study.
‡Results from meta-analysis of individual study results (fixed effects).
CVD, cardiovascular disease.