Rate of complications per 100 treatment years with 95% CI, according to MHV position, intended INR target, or warfarin treatment quality measured as TTR or INR variability, using TTR 70% or the mean INR variability of 0.40 as cut-off
| Bleedings | Thromboses | Death | |
|---|---|---|---|
| Aortic valve prosthesis, N=3656 | |||
| Actual INR 2.2–2.7 | 2.74 (2.41 to 3.12) | 2.42 (2.10 to 2.77) | 1.79 (1.53 to 2.08) |
| Actual INR 2.8–3.3 | 3.02 (2.35 to 3.81) | 2.28 (1.71 to 2.98) | 2.97 (2.36 to 3.69) |
| Mitral valve prosthesis, N=1031 | |||
| Actual INR 2.2–2.7 | 4.73 (3.72 to 5.94) | 2.95 (2.17 to 3.93) | 2.48 (1.80 to 3 to 33) |
| Actual INR 2.8–3.3 | 3.97 (2.89 to 5.33) | 2.63 (1.77 to 3.77) | 4.17 (3.16 to 5.41) |
| Variability | |||
| ≤0.4000 | 2.08 (1.78 to 2.41) | 1.90 (1.61 to 2.22) | 1.51 (1.26 to 1.79) |
| ≥0.4001 | 4.33 (3.87 to 4.82) | 2.96 (2.59 to 3.38) | 3.31 (2.93 to 3.74) |
| TTR | |||
| ≥70% | 2.30 (2.03 to 2.60) | 2.13 (1.86 to 2.41) | 1.68 (1.47 to 1.93) |
| <70% | 5.13 (4.51 to 5.82) | 3.05 (2.58 to 3.59) | 4.00 (3.50 to 4.54) |
INR, international normalised ratio; MHV, mechanical heart valve; TTR, time in therapeutic range.