Multivariable Cox regression, risk of complications according to TTR and INR variability divided into quartiles
| Quartiles | 4 | 3 | 2 | 1 |
|---|---|---|---|---|
| Compl. total | ||||
| TTR | Ref | 1.3 (1.1 to 1.5), p=0.033 | 1.9 (1.6 to 2.3), p<0.001 | 2.4 (2.0 to 2.9), p<0.001 |
| Variability | Ref | 1.1 (0.9 to 1.3), p=NS | 1.4 (1.2 to 1.7), p=0.001 | 2.6 (2.1 to 3.1), p<0.001 |
| Bleedings | ||||
| TTR | Ref | 1.3 (0.9 to 1.8), p=NS | 2.2 (1.7 to 3.0), p<0.001 | 2.9 (2.1 to 3.9), p<0.001 |
| Variability | Ref | 1.2 (0.9 to 1.7), p=NS | 1.8 (1.3 to 2.4), p<0.001 | 2.9 (2.1 to 3.9), p<0.001 |
| Thromboembolic events | ||||
| TTR | Ref | 1.0 (0.8 to 1.4), p=NS | 1.4 (1.1 to 1.9), p=0.015 | 1.4 (1.03 to 2.0), p=0.03 |
| Variability | Ref | 1.1 (0.7 to 1.4), p=NS | 1.2 (0.9 to 1.7), p=NS | 1.8 (1.3 to 2.5), p<0.001 |
| Death | ||||
| TTR | Ref | 1.4 (1.0 to 2.0), p=NS | 2.2 (1.6 to 3.0), p<0.001 | 4.0 (2.9 to 5.4), p<0.001 |
| Variability | Ref | 0.7 (0.5 to 1.1), p=NS | 1.0 (0.8 to 1.5), p=NS | 2.9 (2.2 to 4.0), p<0.001 |
HR is calculated with the highest quartile as reference and adjusted for MHV prosthesis position, AF, heart failure, hypertension, diabetes, stroke and age.
Quartiles TTR, 1: ≤62.18, 2: 76.28–62.19, 3: 86.41–76.29, 4: ≥86.42.
Quartiles INR variability, 1: ≥ 0.5201, 2: 0.4001–0.5200, 3: 0.3001–0.4000, 4: ≤0.3000.
AF, atrial fibrillation; INR, international normalised ratio; MHV, mechanical heart valve; TTR, time in therapeutic range.