HRs with 95% CIs for all-cause mortality, heart failure and myocardial infarction(MI) in relation to treatment for erectile dysfunction, in 48 467 men with a first MI
| All-cause mortality | ||
| Subjects included in analysis* | No ED treatment (n=40 077) | ED treatment (n=3068) |
| Number of deaths (%) | 4741 (11.8) | 112 (3.7) |
| Incidence rate (cases/100 person-years) | 3.54 (3.44–3.64) | 1.43 (1.191.72) |
| Unadjusted, HR (95% CI) | Referent | 0.44 (0.36 to 0.53) |
| Adjusted for age, HR (95% CI) | Referent | 0.60 (0.50 to 0.73) |
| Multivariable adjusted†, HR (95% CI) | Referent | 0.67 (0.55 to 0.81) |
| MI | ||
| Subjects included in analysis* | No ED treatment (n=40 198) | ED treatment (n=2947) |
| Number of MIs (%) | 3089 (7.7) | 99 (3.4) |
| Incidence rate (cases/100 person-years) | 2.43 (2.35 to 2.52) | 1.34 (1.10 to 1.64) |
| Unadjusted, HR (95% CI) | Referent | 0.83 (0.68 to 1.02) |
| Adjusted for age, HR (95% CI) | Referent | 0.91 (0.74 to 1.11) |
| Multivariable adjusted†, HR (95% CI) | Referent | 0.95 (0.77 to1.16) |
| Heart failure | ||
| Subjects included in analysis* | No ED treatment (n=40 144) | ED treatment (n=3001) |
| Number of events (%) | 2403 (6.0) | 41 (1.4) |
| Incidence rate (cases/100 person-years) | 1.86 (1.78–1.93) | 0.54 (0.40–0.73) |
| Unadjusted, HR (95% CI) | Referent | 0.44 (0.32 to 0.60) |
| Adjusted for age, HR (95% CI) | Referent | 0.55 (0.40 to 0.75) |
| Multivariable adjusted†, HR (95% CI) | Referent | 0.60 (0.44 to 0.82) |
* Numbers do not sum up to group total since subjects can be included in the No ED treatment category initially and later change to the ED treatment category.
† Adjusted for all variables in Table 1, except for medication which was adjusted for as a time-dependent variable during follow-up.
erectile dysfunction; MI, myocardial infarction. Incidence rate is given per 100 person-years. †Adjusted for all variables in table 1, except for medication which was adjusted for as a time-dependent variable during follow-up.