Table 3

HRs with 95% CIs for revascularisation, major adverse cardiac events(MACE), cardiovascular or non cardiovascular death, in relation to treatment for erectile dysfunction, in 43 145 men with a first myocardial infarction(MI)

Cardiovascular death
Subjects included in analysis* No ED treatment
(n=40 077)
ED treatment
(n=3068)
Number of deaths (%)2151 (5.4)45 (1.5)
Incidence rate (cases/100 person years)1.61 (1.54–1.68)0.58 (0.43–0.77)
Unadjusted, HR (95% CI)Referent0.40 (0.30 to 0.54)
Adjusted for age, HR (95% CI)Referent0.56 (0.42 to 0.76)
Multivariable adjusted, HR (95% CI)Referent0.64 (0.47 to 0.86)
Non cardiovascular death
Subjects included in analysis* No ED treatment
(n=40 077)
ED treatment
(n=3068)
Number of deaths (%)2590 (6.5)67 (2.2)
Incidence rate (cases/100 person years)1.93 (1.86–2.01)0.86 (0.67–1.09)
Unadjusted, HR (95% CI)Referent0.46 (0.36 to 0.59)
Adjusted for age, HR (95% CI)Referent0.63 (0.49 to 0.81)
Multivariable adjusted, HR (95% CI)Referent0.79 (0.68 to 0.92)
Revascularisation
Subjects included in analysis* No ED treatment
(n=40 443)
ED treatment
(n=2702)
Number of events (%)5381 (13.3)130 (4.8)
Incidence rate (cases/100 person years)4.54 (4.42–4.66)1.96 (1.65–2.33)
Unadjusted, HR (95% CI)Referent0.96 (0.81 to 1.15)
Adjusted for age, HR (95% CI)Referent0.96 (0.80 to 1.14)
Multivariable adjusted, HR (95% CI)Referent0.95 (0.80 to 1.14)
MACE
Subjects included in analysis* No ED treatment
(n=40 522)
ED treatment
(n=2623)
Number of events (%)8317 (20.5)171 (6.5)
Incidence rate (cases/100 person years)7.37 (7.22–7.53)2.67 (2.30–3.11)
Unadjusted, HR (95% CI)Referent0.72 (0.62 to 0.84)
Adjusted for age, HR (95% CI)Referent0.76 (0.66 to 0.89)
Multivariable adjusted, HR (95% CI)Referent0.79 (0.68 to 0.92)
  • * Numbers do not sum up to group total since subjects can be included in the No ED treatment category initially and later change to the ED treatment category

  • Adjusted for all variables in table 1, except for medication which was adjusted for as a time-dependent variable during follow-up.

  • ED, erectile dysfunction; MI, myocardial infarction; MACE, major adverse cardiac event (includes hospital stay for MI, or heart failure, or revascularisation) Incidence rate is given per 100 person-years.