Table 5

Univariable mixed models to investigate how symptom-related variables could help explain the changes in Seattle Angina Questionnaire scores at 6 months

Physical limitationAngina stabilityAngina frequencyTreatment satisfactionQuality of life
Baseline scorep<0.0001p<0.0001p<0.0001p<0.0001p<0.0001
Age (years)p=0.0131p=0.0743p=0.3676p=0.0006p=0.6478
 18–592.4±0.814.5±0.8–−6.1±0.6–
 60–75 0.7±0.912.3±0.8–−3.9±0.6–
Genderp=0.0839p=0.0546p=0.5861p=0.2014p=0.1543
 Female0.4±0.914.7±0.9––16.4±0.8
 Male2.4±0.712.5±0.7––14.8±0.7
History of coronary heart diseasep=0.0204p=0.0142p=0.1495p=0.6387p=0.0010
 Yes−2.3±1.89.3±1.816.3±1.5–10.2±1.7
 No2.1±0.613.9±0.618.6±0.5–16.1±0.6
Exercise ECGp=0.0410p=0.6896p=0.0007p=0.1514p=0.0104
 Normal2.1±0.8–19.9±0.6−4.2±0.616.7±0.7
 Inconclusive−0.7±1.6–15.1±1.3−5.5±1.212.9±1.5
 Abnormal4.5±1.5–15.6±1.3−5.6±1.115.4±1.4
 Not performed−0.9±1.6–17.2±1.2−6.9±1.111.9±1.5
CTCA-defined coronary heart diseasep<0.0001p=0.0167p<0.0001p=0.0907p<0.0001
 Normal (<10%)5.9±1.014.6±1.021.8±0.8−3.9±0.820.1±0.9
 Mild non-obstructive (10–50%)0.9±1.215.4±1.318.3±1.1−4.5±.0915.0±1.2
 Moderate non-obstructive (50–70%)−4.3±1.39.5±1.414.1±1.2−7.5±1.010.7±1.3
 Single-vessel disease1.8±1.716.1±1.716.4±1.4−4.7±1.314.5±1.6
 Two-vessel disease0.7±2.213.4±2.117.4±1.8−2.9±1.614.0±2.0
 Three-vessel disease1.4±2.112.4±2.215.8±1.8−5.5±1.611.2±2.0
Coronary revascularisation*p=0.1164p=0.1316p=0.4093p=0.0437p=0.8591
 Yes4.3±1.815.8±1.7–−2.5±1.3–
 No1.3±0.613.1±0.6–−5.3±0.4–
Preventative therapyp=0.0066p=0.8253p=0.1100p=0.0383p<0.0001
 Cancelled7.1±2.9–23.0±2.4−1.6±2.225.9±2.7
 New therapy initiated−2.0±1.5–15.7±1.2−7.14±1.111.7±1.4
 No change2.0±0.6–18.6±0.5−4.8±0.515.7±0.6

  • Mean±SE.

  • All analyses were adjusted for the baseline score.

  • p Values refer to subcategories that predicted changes in the Seattle Angina Questionnaire at 6 months. The magnitude of changes across individual variables are given where p≤0.15.

  • *Within 6 months of randomisation.

  • CTCA, CT coronary angiography.