Characteristics of patients according to tertiles of sNGALpre-op
| n=1371 | sNGALpre-op | p Value | ||
| First tertile <135 ng/L (n=457) | Second tertile 135 –<220 ng/L (n=456) | Third tertile >220 ng/L (n=458) | ||
| Age/years | 75.4±7.0 | 76.1±6.1 | 76.6±6.6 | 0.03 |
| Male (n (%)) | 302 (66.2) | 342 (75.3) | 345 (75.8) | 0.001 |
| Additive EuroSCORE | 6 (5–7) | 6 (5–7) | 6 (5–8) | 0.03 |
| BMI/kg/m2 | 27.2±4.5 | 27.8±4.5 | 27.7±4.4 | 0.08 |
| Current smoker (n (%)) | 26 (5.7) | 28 (6.2) | 24 (5.3) | 0.45 |
| Diabetes mellitus (n (%)) | 112 (24.6) | 119 (26.2) | 124 (27.3) | 0.65 |
| Dyslipidaemia (n (%)) | 321 (70.4) | 331 (72.9) | 316 (69.5) | 0.50 |
| Hypertension (n (%)) | 345 (75.7) | 340 (74.9) | 353 (77.6) | 0.62 |
| Previous MI (n (%)) | 166 (36.4) | 189 (41.6) | 197 (43.3) | 0.09 |
| Atrial fibrillation (n (%)) | 70 (15.4) | 71 (15.6) | 82 (18.0) | 0.49 |
| PVD (n (%)) | 40 (8.8) | 32 (7.0) | 37 (8.1) | 0.63 |
| Stroke | 51 (11.2) | 53 (11.7) | 51 (11.2) | 0.97 |
| LVEF category (n (%)) | 0.55 | |||
| Good | 300 (68.8) | 296 (67.6) | 276 (63.6) | |
| Moderate | 89 (20.4) | 93 (21.2) | 103 (23.7) | |
| Poor | 47 (10.8) | 49 (11.2) | 55 (12.7) | |
| Baseline creatinine/µmol/L | 83 (73–97) | 91 (76–108) | 95 (80–118) | <0.001 |
| eGFR at baseline/mL/min/1.73 m2 | 75 (62–90) | 71 (59–85) | 67 (53–82) | <0.001 |
| Cardiopulmonary bypass time/hour | 1.75 (1.39–2.20) | 1.72 (1.33–2.23) | 1.77 (1.35–2.35) | 0.34 |
| Cross-clamp time/hour | 1.17 (0.80–1.55) | 1.12 (0.78–1.57) | 1.15 (0.83–1.63) | 0.26 |
| CABG only (n (%)) | 229 (50.2) | 243 (53.3) | 228 (50.1) | 0.55 |
| CABG+valve surgery (n (%)) | 227 (49.8) | 213 (46.7) | 227 (49.9) | |
| Length of ITU stay | 2 (1–4) | 3 (1–5) | 3 (1–5) | <0.001 |
| Length of hospital stay | 9 (7–14) | 10 (7–16) | 12 (8–21) | <0.001 |
| AKI (any) (n (%)) | 135 (30.5) | 186 (41.5) | 206 (45.9) | <0.001 |
| PMI | 112 (24.5) | 102 (22.4) | 118 (25.8) | 0.48 |
| Stroke | 11 (2.4) | 5 (1.1) | 7 (1.5) | 0.29 |
| Revascularisation | 1 (0.2) | 3 (0.7) | 2 (0.4) | 0.60 |
AKI, acute kidney injury; BMI, body mass index; CABG, coronary artery bypass graft surgery; eGFR, estimated glomerular filtration rate; EuroSCORE, European System for Cardiac Operative Risk Evaluation; ITU, intensive care unit; LVEF, left ventricular ejection fraction; MI, myocardial infarction; PMI, perioperative myocardial infarction; PVD, peripheral vascular disease; RIC, remote ischaemic conditioning; sNGALpre-op, preoperative serum neutrophil gelatinase-associated lipocalin.