Associations with incident cardiovascular disease for each predictor variable included in the non-laboratory INTERHEART risk score
| IHRS predictor variables | INTERHEART study regression coefficients (Reference) n=12 676 | PURE study cohort regression coefficients n=1 00 475 | ORs (95% CI) for PURE study regression coefficients | p Value for significance of PURE study regression coefficients |
| Male ≥55 years or female ≥65 years of age | 0.25±0.04 | 0.90±0.05 | 2.46 (2.25 to 2.70) | <0.0001 |
| Parental history of CAD | 0.55±0.06 | 0.11±0.05 | 1.12 (1.00 to 1.24) | 0.044 |
| Diabetes | 0.93±0.06 | 0.68±0.05 | 1.98 (1.78 to 2.20) | <0.0001 |
| Hypertension | 0.72±0.04 | 0.79±0.05 | 2.21 (2.01 to 2.42) | <0.0001 |
| Smoking history | ||||
| Former smoker | 0.22±0.05 | 0.19±0.07 | 1.20 (1.06 to 1.37) | 0.005 |
| 1–5 cigarettes/day | 0.30±0.09 | 0.40±0.08 | 1.49 (1.27 to 1.76) | <0.0001 |
| 6–10 cigarettes/day | 0.53±0.07 | 0.58±0.09 | 1.78 (1.49 to 2.14) | <0.0001 |
| 11–15 cigarettes/day | 0.86±0.10 | 0.46±0.14 | 1.58 (1.19 to 2.10) | 0.002 |
| 16–20 cigarettes/day | 0.98±0.07 | 0.76±0.08 | 2.13 (1.81 to 2.51) | <0.0001 |
| >20 cigarettes/day | 1.45±0.08 | 0.81±0.12 | 2.24 (1.77 to 2.84) | <0.0001 |
| Second-hand smoke exposure | 0.28±0.04 | 0.22±0.08 | 1.24 (1.05 to 1.46) | 0.01 |
| Low physical activity | 0.27±0.06 | 0.15±0.05 | 1.16 (1.04 to 1.30) | 0.006 |
| Depression | 0.39±0.05 | −0.01±0.07 | 0.99 (0.87 to 1.13) | 0.85 |
| General stress | 0.37±0.07 | 0.17±0.06 | 1.19 (1.06 to 1.33) | 0.004 |
| WHR second quartile | 0.10±0.06 | 0.25±0.06 | 1.29 (1.14 to 1.45) | <0.0001 |
| WHR third quartile | 0.17±0.06 | 0.29±0.06 | 1.33 (1.17 to 1.51) | <0.0001 |
| WHR upper quartile | 0.54±0.06 | 0.44±0.06 | 1.55 (1.37 to 1.75) | <0.0001 |
| Dietary variables | ||||
| High salty food consumption (≥1 time/day) | 0.12±0.06 | −0.16±0.06 | 0.86 (0.76 to 0.96) | 0.007 |
| Low fruit consumption (<1 time/day) | 0.16±0.04 | 0.12±0.05 | 1.13 (1.01 to 1.25) | 0.027 |
| Low Vegetable consumption (<1 time/day) | 0.21±0.04 | −0.24±0.07 | 0.79 (0.69 to 0.90) | <0.001 |
| High fried food/trans saturated fat consumption (≥3 times/week) | 0.19±0.06 | −0.02±0.06 | 0.98 (0.87 to 1.10) | 0.76 |
| Red meat/poultry consumption ≥2 times/day | 0.23±0.07 | 0.23±0.05 | 1.26 (1.13 to 1.40) | <0.0001 |
CAD, coronary artery disease; IHRS, INTERHEART Risk Score; PURE, Prospective Urban Rural Epidemiology Study; WHR, waist-to-hip ratio.