Discrimination and calibration of the fasting cholesterol INTERHEART risk score for incident cardiovascular disease
| Outcome*/N (%) | Discrimination | Calibration | ||
| C-statistic (95% CI) | Intercept (95% CI) | Slope (95% CI) | ||
| Original FC-IHRS | ||||
| Overall PURE population | 2681/107 863 (2.49) | 0.71 (0.70 to 0.72) | −3.85 (−3.89 to 3.80) | 0.99 (0.94 to 1.04) |
| Geographic region | ||||
| South Asia | 807/18 957 (4.26) | 0.71 (0.69 to 0.73) | −3.23 (−3.31 to 3.15) | 1.04 (0.95 to 1.13) |
| China | 610/39 129 (1.56) | 0.69 (0.67 to 0.71) | −4.23 (−4.32 to 4.14) | 0.88 (0.78 to 0.98) |
| Southeast Asia | 127/5588 (2.27) | 0.72 (0.68 to 0.76) | −4.09 (−4.32 to 3.87) | 0.99 (0.76 to 1.22) |
| Africa | 114/2762 (4.13) | 0.66 (0.61 to 0.71) | −3.13 (−3.32 to 2.94) | 0.98 (0.66 to 1.30) |
| North America/Europe | 556/17 681 (3.14) | 0.72 (0.70 to 0.74) | −3.71 (−3.81 to 3.60) | 1.04 (0.93 to 1.15) |
| Middle East | 126/5227 (2.41) | 0.78 (0.74 to 0.82) | −3.91 (−4.13 to 3.70) | 1.41 (1.18 to 1.63) |
| South America | 341/18 519 (1.84) | 0.74 (0.71 to 0.77) | −4.35 (−4.49 to 4.21) | 1.11 (0.97 to 1.24) |
| Country income status | ||||
| HIC | 346/13 257 (2.61) | 0.71 (0.68 to 0.73) | −3.79 (−3.91 to 3.67) | 0.95 (0.80 to 1.09) |
| MIC | 1496/74 990 (1.99) | 0.72 (0.71 to 0.73) | −4.11 (−4.17 to 4.05) | 1.02 (0.95 to 1.08) |
| LIC | 839/19 616 (4.28) | 0.71 (0.69 to 0.73) | −3.22 (−3.29 to 3.14) | 1.04 (0.95 to 1.13) |
| Recalibrated FC-IHRS | ||||
| Overall PURE population | 2681/107 863 (2.49) | 0.74 (0.73 to 0.75) | −0.001 (−0.15 to 0.15) | 1 (0.96 to 1.04) |
| Geographic region | ||||
| South Asia | 807/18 957 (4.26) | 0.71 (0.69 to 0.73) | 0 (−0.26, 0.26) | 1 (0.91 to 1.09) |
| China | 610/39 129 (1.56) | 0.69 (0.67 to 0.71) | 0 (−0.46 to 0.46) | 1 (0.89 to 1.11) |
| Southeast Asia | 127/5588 (2.27) | 0.72 (0.68 to 0.76) | 0 (−0.83 to 0.83) | 1 (0.77 to 1.23) |
| Africa | 114/2762 (4.13) | 0.66 (0.61 to 0.71) | 0 (−1.01 to 1.01) | 1 (0.67 to 1.33) |
| North America/Europe | 556/17 681 (3.14) | 0.72 (0.70 to 0.74) | 0 (−0.34 to 0.34) | 1 (0.89 to 1.11) |
| Middle East | 126/5227 (2.41) | 0.78 (0.74 to 0.82) | 0 (−0.55 to 0.55) | 1 (0.84 to 1.16) |
| South America | 341/18 519 (1.84) | 0.74 (0.71 to 0.77) | 0 (−0.45 to 0.45) | 1 (0.88 to 1.12) |
| Country income status | ||||
| HIC | 346/13 257 (2.61) | 0.71 (0.68 to 0.73) | −0.46 (−0.91 to 0.01) | 0.90 (0.76 to 1.03) |
| MIC | 1496/74 990 (1.99) | 0.73 (0.72 to 0.74) | 0.14 (−0.08 to 0.36) | 1.03 (0.97 to 1.09) |
| LIC | 839/19 616 (4.28) | 0.71 (0.69 to 0.73) | 0.01 (−0.25 to 0.26) | 1.00 (0.91 to 1.09) |
*Cardiovascular disease defined as cardiac death, stroke, myocardial infarction, heart failure and revascularisation.
FC-IHRS, fasting cholesterol INTERHEART risk score; HIC, high-income countries; LIC, low-income country; MIC, middle-income country; NL-IHRS, non-laboratory INTERHEART risk score; PURE, Prospective Urban Rural Epidemiology.