Association of MR severity with early and late mortality after SAVR
| Author (ref) | Year | n | MR aetiology | MR grading | Early mortality | Time | p Value | Late mortality | Time (years) | Value | Multivariate analysis HR (95% CI)* |
| Absil 18 | 2003 | 116 | Secondary MR 100% | None/mild Moderate/severe | 3.5% 7.0% | Perioperative | 0.67 | 60.9% 55.0% | 3.2±2.4 | 0.10 | NR |
| Moazami 1 | 2004 | 107 | Secondary MR 100% | Trivial/mild (72) Moderate/severe (35) | NR NR | – | NR | 10.9% 28.6% | 5 | 0.04 | NR |
| Barreiro 21 | 2005 | 408 | Myxomatous 34.3% Calcific 28.5% Ischaemic 15.7% Non-ischaemic 21.4% | None/mild (338) Moderate (70) | 3.8% 7.1% | In-hospital | 0.21 | 40.8% 41.4% | 10 | 1.0 | 1.43 (1.32 to 1.976) |
| Ruel 14 | 2006 | 848 | Secondary MR 100% | None/mild (741) Moderate/severe (107) | NR | – | NR | N/A | 10 | NR | 1.8 (0.9 to 3.4) |
| Caballero-Borrego 20 | 2008 | 572 | Secondary MR 100% | No MR (419) Non-severe MR (153) | 5.6% 10.5% | NR | 0.02 | N/A | – | NR | NR |
| Wan 17 | 2009 | 182 | Secondary MR 100% | None/mild (91) Moderate/severe (91) | NR | 30 days | NR | 56.6% 51.7% | 3.8±3.6 | 0.33 | NR |
| Takeda 16 | 2010 | 193 | NR | None/mild (134) Moderate/severe (59) | 1.7% 2.9% | Operative | 0.6 | 8.2% 8.5% | 3.3±0.5 | 0.49 | NR |
| Barbanti 22 | 2012 | 299 | NR | None/mild (240) Moderate/severe (59) | 7.1% 13.6% | 30 days | 0.09 | 71.9% 50.2% | 1 | 0.04 | 1.77 (1.17 to 2.68) |
| Cotinho 15 | 2013 | 255 | Secondary MR 100% | Severe MR untreated Severe MR surgically treated | 0.0% 1.1% | 30 days | 0.19 | 44.4% 23.3% | 4.48±2.93 | 0.44 | NR |
| Schubert 19 | 2016 | 423 | Secondary MR 96% Rheumatic 3% Leaflet prolapse 1% | Mild (319) Moderate/severe (105) | NR | – | NR | 28.3% 38.2% | 5 | 0.212 | NR |
MR, mitral regurgitation; NR, not reported; SAVR, surgical aortic valve replacement.
*Significant MR and late mortality.