Table 3

Baseline and procedural characteristics of the propensity-matched population, according to anticoagulation therapy at hospital discharge

VariableAnticoagulation therapyP value
No, n=622Yes, n=622
Age (years)81.8±6.781.8±6.10.839
Male sex293 (47.4)289 (46.9)0.864
Body mass index (kg/m2)27.1±5.027.1±5.30.907
Diabetes mellitus168 (27.9)187 (31.2)0.207
Coronary artery disease287 (46.1)293 (47.1)0.776
COPD193 (31.0)186 (29.9)0.712
Atrial fibrillation65 (10.5)497 (79.9)<0.001
CKD (eGFR <60 mL/min)419 (67.4)432 (69.5)0.464
STS7.8±6.67.7±5.70.846
Baseline echocardiogram
 LVEF ≥50%
 Mean gradient (mm Hg)45.2±14.945.2±15.20.973
 Aortic regurgitation
  None/trace375 (63.9)366 (63.4)0.752
  Mild166 (28.3)174 (30.2)
  Moderate40 (6.8)32 (5.6)
  Severe6 (1.0)5 (0.9)
Procedural
 Approach
  Transfemoral497 (79.9)486 (78.1)0.486
  Transapical/transaortic125 (20.1)136 (21.9)
 Prothesis type
  Balloon-expandable295 (47.4)320 (51.5)0.174*
   Cribier-Edwards22 (3.5)22 (3.5)
   SAPIEN104 (16.7)117 (18.8)
   SAPIEN XT139 (22.4)165 (26.5)
   SAPIEN 330 (4.8)16 (2.6)
  Self-expandable327 (52.6)302 (48.6)
   CoreValve258 (41.5)242 (38.9)
   Evolut R36 (5.8)31 (5.0)
   Portico10 (1.6)3 (0.5)
   DirectFlow18 (2.9)13 (2.1)
   Lotus5 (0.8)11 (1.8)
   Other02 (0.3)
 Valve size
  ≤23 mm171 (27.5)176 (28.3)0.800
  >23 mm451 (72.5)446 (71.7)
Discharge echocardiogram
 LVEF ≥50%
 Mean gradient (mm Hg)9.8±4.39.4±4.50.095
 Aortic regurgitation
  None/trace493 (80.3)496 (81.1)0.739
  Mild115 (18.7)107 (17.5)
  Moderate6 (0.9)8 (1.3)
  Severe01 (0.2)
Discharge medication
 Aspirin576 (92.6)359 (57.7)<0.001
 Clopidogrel502 (80.7)202 (32.5)<0.001
  • Categorical variables are reported as n (%); continuous variables are expressed as mean±SD.

  • *Versus self-expandable.

  • CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; LVEF, left ventricular ejection fraction.