Patients with stable angina showing an improvement of at least 25% from baseline, after 28 days’ treatment, in clinical and exercise outcomes, according to study group
| Outcome | Trimetazidine and diltiazem (n=32) n (%) | Placebo and diltiazem (n=32) n (%) | Difference in response % (95% CI) | p value |
|---|---|---|---|---|
| Anginal attacks per week | 28 (87.5) | 15 (46.9) | 40.6 (19.9 to 61.3) | < 0.001 |
| Glyceryl trinitrate tablets per week | 25 (78.1) | 15 (46.9) | 31.2 (8.9 to 53.5) | 0.01 |
| Exercise time | ||||
| At onset of angina | 12 (37.5) | 5 (15.6) | 21.9 (0.9 to 42.9) | < 0.05 |
| At 1 mm ST segment depression | 21 (65.6) | 9 (28.1) | 37.5 (14.9 to 60.1) | 0.003 |
| At peak exercise | 18 (56.3) | 10 (31.3) | 25.0 (1.5 to 48.5) | 0.04 |
| Maximum work at peak exercise | 17 (53.1) | 8 (25) | 28.1 (5.2 to 51.0) | 0.02 |
| Maximum ST segment depression at peak exercise | 11 (34.4) | 10 (31.3) | 3.13 | NS |
CI, confidence interval.