Haemodynamic variables
| Control | Bradykinin | Adenosine 100 μg/min | Glyceryl trinitrate 200 μg/min | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.5 μg/min | 1.5 μg/min | 2.5 μg/min | |||||||
| Before L-NMMA infusion | |||||||||
| Mean AP (mm Hg) | 106 (3) | 105 (2) | 104 (3)1-150 | 103 (2)** | 104 (3) | ||||
| HR (beats/min) | 64 (3) | 65 (3) | 65 (3) | 66 (3) | 64 (2) | ||||
| RPP (mm Hg × beats/min) | 9428 (493) | 9577 (499) | 9315 (505) | 9401 (508) | 9096 (436) | ||||
| After L-NMMA infusion | |||||||||
| Mean AP (mm Hg) | 108 (3) | 108 (3) | 106 (3) | 105 (3)1-150 | 96 (3)** | ||||
| HR (beats/min) | 63 (2) | 62 (3) | 63 (3) | 64 (3) | 73 (3)** | ||||
| RPP (mm Hg × beats/min) | 9275 (529) | 9351 (604) | 9354 (609) | 9304 (595) | 9056 (529) | ||||
Values are mean (SEM).
↵1-150 p<0.05, **p<0.01 v control.
AP, arterial pressure; HR, heart rate; L-NMMA, NG-monomethyl-L-arginine; RPP, rate–pressure product.