Symptoms, exercise capacity, blood pressure, and heart rate
| Metoprolol (week) | Celiprolol (week) | Placebo (week) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 4 | 8 | 12 | 0 | 4 | 8 | 12 | 0 | 4 | 8 | 12 | |||
| Symptom questionnaire score | 18.1 (3.5) | 14.5 (3.9) | 13.5 (3.3) | 9.6 (2.5)2-165 | 13.5 (2.7) | 11.8 (1.9) | 8.5 (1.7) | 8.1 (1.7)* | 7.7 (2.9) | 4.6 (2.2) | 6.4 (3.2) | 5.8 (2.4) | ||
| NYHA functional class | ||||||||||||||
| I | 0 | 2 | 2 | 3 | 0 | 1 | 2 | 2 | 0 | 1 | 1 | 1 | ||
| II | 8 | 10 | 10 | 12 | 9 | 12 | 11 | 9 | 5 | 4 | 5 | 4 | ||
| III | 11 | 7 | 5 | 2 | 10 | 5 | 5 | 6 | 5 | 4 | 2 | 1 | ||
| IV | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | ||
| Mean | 2.6 (0.12) | 2.2 (0.15) | 2.2 (0.15) | 1.94 (0.13)2-165 | 2.7 (0.15) | 2.3 (0.15) | 2.17 (0.15) | 2.2 (0.17) | 2.5 (0.15) | 2.3 (0.16) | 2.1 (0.2) | 2.5 (0.3) | ||
| Blood pressure (mm Hg) | ||||||||||||||
| Sitting systolic | 114 (5) | 110 (5) | 109 (5) | 107 (4) | 113 (4) | 109 (4) | 112 (4) | 110 (5) | 105 (6) | 106 (5) | 105 (7) | 104 (8) | ||
| Sitting diastolic | 70 (3) | 70 (2) | 65 (3) | 63 (2) | 71 (2) | 67 (3) | 67 (2) | 68 (3) | 65 (3) | 64 (4) | 63 (3) | 64 (5) | ||
| Standing systolic | 119 (6) | 114 (5) | 109 (5) | 111 (5) | 114 (4) | 113 (3) | 117 (4) | 112 (5) | 107 (6) | 105 (5) | 107 (4) | 109 (5) | ||
| Standing diastolic | 76 (3) | 74 (2) | 68 (3) | 69 (2) | 74 (2) | 72 (2) | 71 (2) | 73 (3) | 68 (4) | 68 (5) | 69 (4) | 68 (4) | ||
| ETT (6 min walk, feet) | 1246 (54) | 1306 (53) | 1306 (56) | 1402 (52)2-165 | 1191 (55) | 1200 (61) | 1252 (61) | 1256 (61)* | 1304 (69) | 1463 (89) | 1421 (70) | 1397 (72) | ||
| Heart rate (beats/min) | 79.3 (2.5) | 67.6 (2.6) | 66.9 (2.6) | 62.1 (2.6)2-165 | 77.9 (2.8) | 74.1 (2.7) | 74.7 (3.2) | 74.7 (2.4) | 79.5 (3.5) | 81.6 (4.1) | 84.3 (3.8) | 76.8 (4.4) | ||
Values are means (SEM).
↵2-165 p<0.001; *p<0.05 v baseline.
ETT, exercise tolerance test; FS, fractional shortening; NYHA, New York Heart Association.