Changes in diastolic function by Doppler echocardiography between weeks 0 and 12
| Metoprolol | Celiprolol | Placebo | ||||||
|---|---|---|---|---|---|---|---|---|
| 0 | 12 | 0 | 12 | 0 | 12 | |||
| Mitral E/A | 1.35 (0.3) | 1.09 (0.2) | 1.32 (0.3) | 1.38 (0.3) | 1.65 (0.5) | 1.53 (0.5) | ||
| Mitral DT (ms) | 149 (32) | 207 (25) | 152 (11) | 144 (10) | 136 (19) | 157 (33) | ||
| LV IVRT (ms) | 125 (8) | 135 (9) | 126 (14) | 129 (9) | 119 (18) | 154 (45) | ||
| RFP (%) | 62 | 50 | 50 | 67 | 67 | 50 | ||
| ARP (%) | 25 | 50 | 50 | 33 | 17 | 17 | ||
| Normal pattern (%) | 12 | 0 | 0 | 0 | 17 | 33 | ||
Values are means (SEM) unless otherwise stated.
ARP, abnormal relaxation pattern; DT, deceleration time of E wave; E/A, ratio of peak early E wave velocity over peak A wave velocity; LV IVRT, left ventricular isovolumic relaxation time; RFP, restrictive filling pattern.