Systemic haemodynamics, forearm blood flow, and lower body negative pressure (LBNP) responses during saline and losartan infusions
| Control subjects (n = 8) | Patients with heart failure (n = 8) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Saline | Losartan 30 μg/min | Losartan 90 μg/min | Saline | Saline | Losartan 30 μg/min | Losartan 90 μg/min | Saline | ||
| Blood pressure (mm Hg) | |||||||||
| Systolic | 129 (4) | 132 (4) | 128 (5) | 133 (4) | 134 (9) | 134 (9) | 139 (9) | 133 (9) | |
| Diastolic | 86 (4) | 86 (6) | 85 (3) | 83 (3) | 83 (6) | 85 (7) | 85 (6) | 81 (6) | |
| Heart rate (beats/min) | 74 (3) | 68 (3) | 65 (4) | 63 (3) | 64 (2) | 63 (2) | 62 (2) | 63 (2) | |
| Absolute forearm blood flow (ml/100ml/min) | |||||||||
| Non-infused arm | 3.8 (0.7) | 4.1 (1.0) | 4.2 (1.0) | 4.8 (1.2) | 2.9 (0.5) | 2.7 (0.3) | 2.7 (0.2) | 2.6 (0.2) | |
| Infused arm | 4.3 (0.8) | 4.7 (1.2) | 4.7 (1.2) | 4.8 (1.1) | 3.1 (0.5) | 3.4 (0.5) | 3.6 (0.4) | 3.2 (0.5)2-150 | |
| Percentage change in forearm blood flow | 1 (2) | 1 (3) | −1 (4) | −5 (5) | 0 (2) | 13 (5) | 26 (7) | 12 (5)† | |
| Absolute forearm blood flow with LBNP (ml/100ml/min) | |||||||||
| Non-infused arm | 3.1 (0.6) | 3.3 (0.8) | 3.3 (0.8) | 3.5 (0.9) | 2.4 (0.3) | 2.4 (0.3) | 2.3 (0.2) | 2.3 (0.2) | |
| Infused arm | 3.4 (0.7) | 3.5 (0.9) | 3.7 (1.0) | 4.0 (1.2) | 2.5 (0.3) | 2.8 (0.4) | 3.0 (0.2) | 2.7 (0.3) | |
| Percentage vasoconstriction with LBNP | |||||||||
| Non-infused arm | 19 (4) | 20 (4) | 21 (2) | 20 (5)‡ | 13 (5) | 11 (4) | 12 (5) | 13 (3) | |
| Infused arm | 20 (5) | 24 (3) | 24 (4) | 18 (4)‡ | 14 (6) | 15 (4) | 15 (5) | 14 (5) | |
↵2-150 p < 0.001 (two way anova: infusedv non-infused); †p < 0.001 (two wayanova: patients v controls);‡p = 0.008 (two way anova: basal vLBNP).