Results of genetic and cardiac analyses in patients with MELAS
| Case | Sex | Age at final examination (years) | mtDNA mutation | ECG findings | UCG diagnosis |
|---|---|---|---|---|---|
| 1 | F | 23 | 3243 | Intermittent WPW; inverted T wave in II, III, aVF, V5, V6; | HCM |
| 2 | F | 22 (lost) | 3243 | Inverted T wave in III, V6 | HCM→DCM |
| 3 | M | 21 | 3243 | WPW | HCM→DCM |
| 4 | M | 6 | 3243 | WPW | Normal |
| 5 | M | 8 | 3243 | Flat T wave in V5-V6 | Normal |
| 6 | M | 7 | 3243 | ST-T down slope at first, then normalised | Initially LV dilatation; during follow up, normal size |
| 7 | M | 15 | 3471 | Normal | Not done |
| 8 | M | 22 | 3243 | Inverted T wave in aVL | Normal |
| 9 | F | 11 | 3243 | Normal | Not done |
| 10 | M | 17 (lost) | 3243 | Inverted T wave in II, III, aVF, V5, V6 | Normal |
| 11 | M | 13 | 3243 | PVC | Normal |
DCM, dilated cardiomyopathy; HCM, hypertrophic cardiomyopathy; LV, left ventricle; mtDNA, mitochondrial DNA; MELAS, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes; PVC, premature ventricular contractions; UCG, ultrasound cardiogram; WPW, Wolff-Parkinson-White syndrome.