Effects of L-arginine and placebo infusion on resting (supine) and exercise induced (seated) systemic blood pressure and heart rate in patients with chronic heart failure
| Time after infusion (min) | Exercise | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 10 | 20 | 30 | Pre | Post | Difference | |||
| Systolic blood pressure (mm Hg) | |||||||||
| L-arginine | 121 (4) | 116 (4) | 122 (4) | 125 (5) | 123 (4) | 164 (7)1-160 | NS | ||
| Placebo | 122 (5) | 123 (4) | 123 (5) | 125 (5) | 131 (6) | 163 (6)1-160 | |||
| Diastolic blood pressure (mm Hg) | |||||||||
| L-arginine | 75 (3) | 67 (3) | 71 (4) | 72 (3) | 71 (3) | 90 (4)1-160 | NS | ||
| Placebo | 72 (3) | 72 (2) | 71 (2) | 74 (3) | 72 (3) | 91 (6)1-160 | |||
| Heart rate (beats/min) | |||||||||
| L-arginine | 66 (4) | 64 (3) | 66 (3) | 69 (3) | 82 (4) | 135 (7)1-160 | NS | ||
| Placebo | 65 (4) | 63 (4) | 63 (4) | 65 (3) | 78 (4) | 129 (7)1-160 | |||
Values are mean (SEM).
↵1-160 p < 0.01 v pre-exercise.