Effect of L-arginine and placebo infusions on plasma concentrations of L-arginine, L-citrulline, noradrenaline, adrenaline, dopamine, and insulin in patients with chronic heart failure
| Baseline | After infusion | After exercise | Differences | ||
|---|---|---|---|---|---|
| Plasma L-arginine (pg/ml) | |||||
| L-arginine | 25 (7) | 1306 (95)** | 464 (30)** | – | |
| Placebo | – | – | – | ||
| Plasma L-citrulline (pg/ml) | |||||
| L-arginine | 8.2 (0.4) | 10.1 (0.5)** | 11.6 (0.6)** | – | |
| Placebo | – | – | – | ||
| Plasma noradrenaline (pg/ml) | |||||
| L-arginine | 307 (47) | 320 (53) | 1359 (238)** | NS | |
| Placebo | 297 (32) | 268 (33) | 1293 (287)** | ||
| Plasma adrenaline (pg/ml) | |||||
| L-arginine | 40 (11) | 41 (10) | 144 (23)2-150 | NS | |
| Placebo | 44 (10) | 39 (12) | 144 (47)2-150 | ||
| Plasma dopamine (pg/ml) | |||||
| L-arginine | 33 (12) | 29 (11) | 36 (8) | NS | |
| Placebo | 29 (12) | 26 (11) | 44 (15) | ||
| Plasma insulin (IU/ml) | |||||
| L-arginine | 20 (4) | 67 (15)2-150 | 16 (5) | p < 0.05 | |
| Placebo | 27 (6) | 46 (12)2-150 | 21 (6) | ||
Values are mean (SEM).
↵2-150 p < 0.05; **p < 0.01 v baseline.