Evolution of heart variability in control state and during treatment with d,l-sotalol
| Group I | Group II | ||||
|---|---|---|---|---|---|
| Control | Sotalol | Control | Sotalol | ||
| SDNN (ms) | 90 (25) | 116 (142) | 113.5 (37) | 96 (28) | |
| pNN50 (%) | 5 (4) | 10 (10)* | 5 (5) | 9 (7) | |
| NN (ms) | 845 (134) | 1007 (116)** | 891 (117) | 1067.5 (125)*** | |
| CV (%) | 11 (3) | 11.5 (4) | 13 (4) | 9 (2)*** | |
| rMSSD (ms) | 25 (15) | 39 (20)* | 27 (12) | 38 (14)* | |
| LF (ms) | 345 (395) | 432 (466) | 263 (225) | 376 (288) | |
| HF (ms) | 75 (68) | 146 (134)* | 60 (49) | 125 (79)* | |
| LF/HF radio | 3.94 (2.63) | 3.05 (1.24) | 4.74 (3.02) | 3.00 (2.02)* | |
Values are mean (SD).
Comparisons were made in each group between control values and values with sotalol: *p < 0.05; **p < 0.01; ***p < 0.001.
CV, coefficient of variance (SDNN/mean RR); group I, responders tod,l-sotalol (inducibility of ventricular tachycardia suppressed); group II, non-responders to d,l-sotalol; HF, high frequency amplitude; LF, low frequency amplitude; NN, mean RR interval; pNN50, per cent differences between normal RR intervals that are greater than 50 ms, computed over 24 hours; rMSSD, root mean square of successive differences in RR intervals among consecutive normal beats; SDNN, standard deviation of the mean RR intervals.