Evalution of ventricular tachycardia rate and heart rate variability in the control state and during treatment with sotalol in group II patients
| Sotalol positive (n = 8) | Sotalol negative (n = 14) | |||||
|---|---|---|---|---|---|---|
| Control | Sotalol | Control | Sotalol | |||
| VT rate (beats/min) | 260 (33) | 201 (13) | 215 (34) | 227 (29) | ||
| SDNN (ms) | 112 (30) | 107 (29) | 113 (39) | 90 (27) | ||
| pNN 50 (%) | 7 (4) | 10.5 (5) | 3.4 (5) | 7.7 (6) | ||
| NN (ms) | 911 (88) | 1229 (96)*** | 879 (136) | 1046 (133)*** | ||
| CV (%) | 12 (3) | 9 (2) | 13 (5) | 9 (3)** | ||
| rMSSD (ms) | 35 (11) | 40 (11) | 27 (22.5) | 33 (14) | ||
| LF (ms) | 388 (254) | 476 (193) | 189 (177) | 310 (320) | ||
| HF (ms2) | 95 (54) | 149 (52) | 38 (32)* | 97 (76)** | ||
| LH/HF ratio | 4.02 (1.87) | 2.52 (1.44) | 4.87 (3.60) | 3.12 (2.30) | ||
Values are mean (SD).
Comparisons are made between control state and sotalol in each group:*p < 0.05; **p < 0.01; ***p < 0.001.
CV, coefficient of variance (SDNN/mean RR); HF, high frequency amplitude; LF, low frequency amplitude; NN, mean RR interval; pNN50, per cent differences between normal RR intervals that are greater than 50 ms, computed over 24 hours; rMSSD, root mean square of successive differences in RR intervals among consecutive normal beats; SDNN, standard deviation of the mean RR intervals; sotalol negative, unchanged or accelerated VT with sotalol; sotalol positive, slowed VT with sotalol; VT, ventricular tachycardia.