Reactivity of proximal and distal segments and coronary stenoses to substance P and glyceryl trinitrate in patients with normal angiograms and in patients with stable angina
| Minimum luminal diameter (mm) | |||||
|---|---|---|---|---|---|
| Saline 1 | Substance P (5.6 pmol) | Substance P (27.8 pmol) | Saline 2 | Glyceryl trinitrate | |
| Stable angina | |||||
| Proximal (n = 50) | 3.10 (0.09) [0.7 (0.2)%] | 3.19 (0.10) [7.3 (1.4)%] | 3.28 (0.09) [7.9 (1.3)%] | 3.12 (0.09) [1.1 (0.2)%] | 3.35 (0.09) [10.2 (1.6)%] |
| Distal (n = 59) | 1.35 (0.04) [1.0 (0.3)%] | 1.52 (0.05) [13.9 (1.9)%]1-150 | 1.54 (0.05) [16.1 (1.6)%]1-150 | 1.37 (0.04) [1.5 (0.3)%] | 1.64 (0.05) [21.5 (1.7)%]1-150 |
| Stenoses (n = 28) | 1.56 (0.08) [1.1 (0.3)%] | 1.68 (0.10) [9.6 (1.5)%] | 1.74 (0.10) [11.9 (1.8)%] | 1.58 (0.08) [1.4 (0.3)%] | 1.79 (0.10) [16.3 (1.8)%]1-160 |
| Normal coronary arteries | |||||
| Proximal (n = 19) | 3.03 (0.16) [0.4 (0.4)%] | 3.33 (0.16) [11.5 (2.3)%] | 3.43 (0.23) [15.0 (2.3)%]1-151 | 3.07 (0.16) [1.1 (0.4)%] | 3.53 (0.24) [18.4 (2.9)%]1-151 |
| Distal (n = 27) | 1.48 (0.04) [0.3 (0.5)%] | 1.68 (0.05) [14.5 (2.2)%] | 1.71 (0.05) [15.9 (1.6)%] | 1.50 (0.04) [0.9 (0.5)%] | 1.74 (0.06) [18.5 (2.7)%] |