Sensitivity, specificity, pre- and post-test probabilities, positive and negative predictive values (NPV and PPV) of individual cardiac markers for SCEs at 0, 4, 8, 16, and 24 hours after admission to hospital
| Time (hours) | Marker | False negatives (n)3-150 | Sensitivity (95% CI) | Specificity (95% CI) | NPV3-151 (95% CI) | PPV3-152 (95% CI) | Pretest probability3-153 |
|---|---|---|---|---|---|---|---|
| 0 | Myoglobin | 16 | 33.3 (26.6 to 40.9) | 79.7 (72.9 to 85.2) | 88.4 (81.6 to 93.0) | 20.5 (10.6 to 36.0) | 13.6 |
| 4 | Myoglobin | 11 | 50.0 (42.6 to 57.4) | 76.8 (70.0 to 82.6) | 92.0 (85.8 to 95.7) | 22.5 (12.9 to 36.2) | 11.8 |
| 8 | Myoglobin | 10 | 58.3 (51.0 to 65.3) | 77.8 (71.2 to 83.4) | 92.9 (86.9 to 96.3) | 27.4 (17.0 to 41.2) | 12.6 |
| 16 | Myoglobin | 13 | 48.0 (40.6 to 55.5) | 81.5 (75.0 to 86.7) | 90.8 (84.4 to 94.8) | 29.3 (17.4 to 44.8) | 13.7 |
| 24 | Myoglobin | 14 | 39.1 (31.4 to 47.4) | 81.4 (74.1 to 87.1) | 88.2 (80.7 to 93.2) | 27.3 (14.8 to 44.7) | 15.1 |
| 0 | CK-MBmass | 15 | 37.5 (30.4 to 45.1) | 94.8 (90.1 to 97.4) | 90.6 (84.7 to 94.5) | 52.9 (30.3 to 74.5) | 13.6 |
| 4 | CK-MBmass | 4 | 78.9 (72.2 to 84.4) | 93.9 (89.2 to 96.8) | 97.5 (93.3 to 99.2) | 60.0 (40.3 to 77.0) | 10.3 |
| 8 | CK-MBmass | 4 | 84.0 (78.0 to 88.7) | 95.3 (91.1 to 97.7) | 97.6 (93.6 to 99.2) | 72.4 (53.8 to 85.6) | 12.7 |
| 16 | CK-MBmass | 4 | 84.0 (77.7 to 88.8) | 94.3 (89.6 to 97.0) | 97.4 (93.0 to 99.2) | 70.0 (51.7 to 83.6) | 13.7 |
| 24 | CK-MBmass | 8 | 65.2 (57.0 to 72.7) | 95.3 (90.2 to 97.9) | 93.8 (87.8 to 97.1) | 71.4 (49.2 to 86.6) | 15.2 |
| 0 | MLC 1 | 14 | 44.0 (36.8 to 51.5) | 68.6 (61.2 to 75.1) | 88.6 (81.3 to 93.4) | 18.0 (10.3 to 29.7) | 13.6 |
| 4 | MLC 1 | 6 | 75.0 (68.1 to 80.9) | 65.9 (58.5 to 72.5) | 94.7 (88.4 to 97.8) | 24.3 (15.9 to 35.3) | 12.8 |
| 8 | MLC 1 | 6 | 78.6 (72.1 to 83.9) | 63.5 (56.4 to 70.2) | 94.7 (88.4 to 97.8) | 26.2 (17.9 to 36.6) | 14.1 |
| 16 | MLC 1 | 5 | 81.5 (75.0 to 86.6) | 63.4 (56.0 to 70.2) | 95.3 (88.9 to 98.3) | 27.2 (18.6 to 37.8) | 14.4 |
| 24 | MLC 1 | 5 | 80.0 (72.8 to 85.7) | 66.2 (58.3 to 73.3) | 94.7 (87.6 to 98.0) | 30.3 (20.5 to 42.4) | 15.5 |
| 0 | cTnI | 14 | 44.0 (36.8 to 51.5) | 93.8 (89.0 to 96.6) | 91.5 (85.8 to 95.1) | 52.4 (31.8 to 72.2) | 13.5 |
| 4 | cTnI | 3 | 87.0 (81.1 to 91.2) | 91.0 (85.7 to 94.5) | 98.1 (94.0 to 99.5) | 57.1 (40.6 to 72.3) | 12.2 |
| 8 | cTnI | 3 | 88.9 (83.4 to 92.7) | 91.3 (86.2 to 94.7) | 98.1 (94.2 to 99.5) | 61.5 (45.6 to 75.3) | 13.6 |
| 16 | cTnI | 3 | 88.9 (83.3 to 92.8) | 90.7 (85.4 to 94.3) | 98.0 (93.8 to 99.5) | 61.5 (45.6 to 75.3) | 14.3 |
| 24 | cTnI | 3 | 88.0 (81.7 to 92.4) | 90.4 (84.6 to 94.3) | 97.6 (92.7 to 99.4) | 62.9 (46.0 to 77.1) | 15.5 |
↵3-150 Patients sustaining an SCE despite negative marker at this timepoint.
↵3-151 Probability of a patient avoiding any SCEs in hospital after a negative test result.
↵3-152 Probability of a patient experiencing an SCE in hospital after a positive test result.
↵3-153 Probability of a patient experiencing an SCE in hospital before applying the results of tests.
Post-test probability (%) of a patient suffering an SCE after a negative test = 100 − NPV.