Whole cohort (n = 61) |
AS (n = 44) |
AR (n = 17) |
AS v AR p value | ||||
Clinical parameters1-150 | |||||||
Mean (SD) age (years) | 65 (12) | 68 (10) | 59 (14) | t = −2.6 | 0. 01 | ||
Males:females | 36:25 | 23:21 | 13:4 | χ2 = 2.97; df = 1 | 0.08 | ||
Mean (SD) body surface area | 1.8 (0.2) | 1.8 (0.2) | 1.8 (0.2) | t = −0.5 | 0.6 | ||
Aetiology | |||||||
Calcification | 69 (42) | 89 (39) | 18 (3) | ||||
Rheumatic | 8 (5) | 7 (3) | 12 (2) | ||||
Myxomatous | 13 (8) | – | 47 (8) | ||||
Others | 11(6) | 5 (2) | 25 (4) | ||||
NYHA class | |||||||
I and II | 62 (38) | 43 (24) | 82 (14) | χ2 = 4.04; df = 1 | 0.04 | ||
III and IV | 38 (23) | 57 (20) | 18 (3) | ||||
Antithrombotic treatment | |||||||
Aspirin | 41 (25) | 48 (21) | 14 (4) | χ2 = 2.9; df = 1 | 0.08 | ||
Echocardiographic data | |||||||
Mean (SD) transvalvar gradient | – | 74 (34) | – | ||||
Severity of AR | |||||||
Moderate | – | – | 35 (6) | ||||
Severe | – | – | 65 (11) | ||||
Mean (SD) plasma concentrations of coagulation markers | |||||||
Plasma fibrinogen (g/l) | 3.6 (0.6) | 3.4 (1.3) | 0.3 | ||||
Soluble P-selectin (ng/ml) | 80 (37) | 92 (32) | 0.3 | ||||
von Willebrand factor (IU/dL) | 127 (31) | 120 (42) | 0.4 |
↵1-150 Values are percentages (numbers) unless otherwise specified