The effects of BQ-123 on the studied variables in 14 individuals, mean (SEM) age 53 (2) years (nine men, five women)
| Variables | Baseline | BQ-123 | p Value | ||
|---|---|---|---|---|---|
| Heart rate (beats/min) | All 14 subjects | 78 (2) | 78 (2) | NS | |
| CAD (n=7) | 76 (3) | 76 (4) | NS | ||
| Normal CA (n=7) | 79 (3) | 78 (3) | NS | ||
| Mean blood pressure (mm Hg) | All 14 subjects | 110 (3) | 110 (5) | NS | |
| CAD (n=7) | 109 (5) | 102 (5) | NS | ||
| Normal CA (n=7) | 111 (5) | 118 (8) | NS | ||
| Proximal artery segment (mm) | All 14 subjects | 2.90 (0.12) | 3.06 (0.13) | 0.03 | |
| CAD (n=7) | 2.92 (0.18) | 3.19 (0.23) | 0.01 | ||
| Normal CA (n=7) | 2.88 (0.18) | 2.94 (0.14) | NS | ||
| Distal artery segment (mm) | All 14 subjects | 1.50 (0.08) | 1.67 (0.07) | 0.0003 | |
| CAD (n=7) | 1.48 (0.12) | 1.66 (0.10) | 0.005 | ||
| Normal CA (n=7) | 1.51 (0.09) | 1.67 (0.10) | 0.008 | ||
| PVi (cm) | All 14 subjects | 13.7 (1.0) | 16.0 (1.3) | 0.06 | |
| CAD (n=7) | 13.7 (1.3) | 15.6 (1.4) | NS | ||
| Normal CA (n=7) | 13.6 (1.5) | 16.4 (2.4) | NS | ||
| CBF (ml/min) | All 14 subjects | 75 (10) | 92 (10) | 0.006 | |
| CAD (n=7) | 73 (12) | 94 (13) | 0.02 | ||
| Normal CA (n=7) | 77 (17) | 89 (15) | NS | ||
| CVR (mm Hg/ml/min) | All 14 subjects | 1.99 (0.36) | 1.44 (0.22) | 0.02 | |
| CAD (n=7) | 1.84 (0.42) | 1.20 (0.18) | NS | ||
| Normal CA (n=7) | 2.14 (0.62) | 1.68 (0.41) | NS | ||
| Plasma big ET-1 (fmol/ml) | All 14 studied subjects | 0.28 (0.03) | 0.33 (0.04) | NS | |
| CAD (n=7) | 0.28 (0.03) | 0.28 (0.02) | NS | ||
| Normal CA (n=7) | 0.29 (0.05) | 0.39 (0.08) | NS | ||
Seven subjects had normal coronary arteries (CA) and seven had coronary artery disease (CAD). Values are given as mean (SEM). For rest of abbreviations see table 2.