Study | n | Symptoms at entry | Mean (range) age (years) | Conclusions |
Henry 1980 | 49 | Yes | 46 (19–68) | Pre-op ESD > 55 mm and FS < 25% were associated with poor outcome post AVR |
Henry 1980 | 37 | No | 35 (17–64) | ESD and FS predicted which patients became symptomatic and required AVR |
Bonow 1983 | 77 | No | 37 (16–67) | AVR is not needed until symptoms or LV dysfunction occurs |
Bonow 1984 | 37 | Yes | 41 (20–46) | Duration of pre-op LV dysfunction is an important predictor of reversibility of LV function |
Taniguchi 1987 | 62 | Yes | 43 (18–64) | Pre-op LV-ES volume index was most important predictor of subsequent cardiac death |
Bonow 1988 | 61 | Yes | 43 (19–72) | Long term improvement in LV function is related to early reduction in EDD post-op |
Siemienczuk 1989 | 50 | No | 48 (16)2-150 | Patients can be risk stratified for “early progression to AVR” based on measurement of LV size and function |
Taniguchi 1990 | 35 | Yes | 43 (15–60) | The post-op increase in EF correlated with the decrease in ESS. Contractile dysfunction persisted |
Bonow 1991 | 104 | No | 36 (17–67) | Multivariate predictors of outcome (death, ventricular dysfunction or symptoms) were age, initial ESD, and rate of change in ESD and rest EF |
Pirwitz 1994 | 27 | Yes | (18–72) | The peak systolic pressure to ESV ratio was the strongest predictor of postoperative (post-op) functional class |
Klodas 1996 | 31 | Yes | 50 (15)2-150 | Pre-op EF (not EDD) predicted late survival and post-op EF. Severe LV dilation is not a contraindication to surgery |
Borer 1997 | 104 | No | 46 (15)2-150 | Change in EF from rest to exercise (normalise to the change in wall stress) was the strongest predictor of outcome |
Dujardin 1999 | 264 | No | 56 (19)2-150 | Predictors of outcome were age, functional class, comorbidity, AF, and ESD |
AF, atrial fibrillation; AVR, aortic valve replacement; EF, ejection fraction; EDD, end diastolic dimension; ESD, end systolic dimension; ESS, end systolic stress; ESV, end systolic volume; FS, functional shortening; LV, left ventricular;
↵2-150 SD.
Sources: Henry WL, et al. Circulation1980;61:71–483; Henry WL,et al. Circulation1980;61:484–92; Bonow RO.Circulation1983;68:509–17; Taniguchi K,et al. J Am Coll Cardiol 1987;10:510–18; Bonow RO.Circulation1988;78(II):108–20; Siemienczuk D,et al. Ann Intern Med 1989;110:587–92; Taniguchi K,et al. Circulation1990;82:798–807; Bonow RO.Circulation1991;84:1625–35; Pirwitz MJ,et al. J Am Coll Cardiol 1994;24:1672–7; Klodas E,et al. J Am Coll Cardiol 1996;27:670–7; Borer JS,et al. Circulation1997; 97: 525–34; Dujardin KS,et al. Circulation1999; 99:1851–7.