Clinical features of patients with dilated cardiomyopathy according to genotype
| Variable | C282Y present | p Value | H63D present | p Value | |||||
|---|---|---|---|---|---|---|---|---|---|
| Yes (n=31) | No (n=176) | Yes (n=74) | No (n=132) | ||||||
| Age (years) | 44.2 (2.9) | 42.4 (1.1) | NS | 41.5 (1.7) | 43.2 (1.3) | NS | |||
| LVDD (mm) | 59.9 (1.7) | 64.9 (0.9) | 0.03 | 64.4 (1.4) | 63.8 (11.1) | NS | |||
| LVSD (mm) | 45.7 (2.4) | 52.9 (1.1) | 0.01 | 51.9 (1.7) | 51.8 (13.4) | NS | |||
| NYHA class | 1.4 (0.2) | 1.6 (0.1) | NS | 1.4 (0.1) | 1.7 (0.1) | NS | |||
| Peak Vo2 (ml/kg/min) | 23.1 (10.2) | 20.9 (8.9) | NS | 20.5 (9.3) | 21.6 (9.0) | NS | |||
| Familial disease | 10 (32.3) | 49 (27.8) | NS | 21 (28.4) | 37 (28.0) | NS | |||
| Ethanol3-150 | 23 (79.3) | 127 (79.9) | NS | 57 (82.6) | 93 (78.8) | NS | |||
| Atrial fibrillation | 2 (7.4) | 31 (19.7) | NS | 11 (16.4) | 21 (18.1) | NS | |||
| Ventricular tachycardia | 7 (22.6) | 58 (33.0) | NS | 22 (29.7) | 43 (32.6) | NS | |||
| Change in LVDD at follow up (mm) | 3.6 (1.2) | 1.2 (0.5) | NS | 1.1 (0.9) | 1.9 (0.6) | NS | |||
| Death/transplant | 5 (16.1) | 48 (27.3) | NS | 22 (29.7) | 30 (22.7) | NS | |||
Values are mean (SD) for continuous variables and n (%) for categorical variables.
↵3-150 Consumption of > 5 units/week.
LVDD, left ventricular end diastolic dimension; LVSD, left ventricular end systolic dimension; NYHA, New York Heart Association functional class; Vo2, oxygen consumption.