Total methionine and homocysteine concentrations, basal blood flow, and area under the curve (AUC) for change in blood flow following oral methionine and homocysteine
| Study 1 | Study 2 | ||||||
|---|---|---|---|---|---|---|---|
| Placebo | Methionine | Placebo | Homocysteine | ||||
| Total methionine (μmol/l) | Baseline | 22 (20.5 to 23.5) | 23.2 (19.1 to 27.3) | ||||
| t=4 hours | 545 (495 to 595)1-150 | 30.4 (24.5 to 36.3) | |||||
| Total homocysteine (μmol/l) | Baseline | 8.4 (6.0 to 10.8) | 8.5 (6.1 to 10.8) | 8.3 (6.6 to 10.0) | 8.8 (7.9 to 9.7) | ||
| t=4 hours | 9.2 (7.2 to 11.2) | 27.3 (21.0 to 33.6)1-150 | 8.2 (6.1 to 10.1) | 35.7 (30.5 to 40.9)1-150 | |||
| Basal FBF (ml/100 ml/min) | 2.9 (2.2 to 3.6) | 2.9 (2.1 to 3.7) | 4.0 (3.3 to 4.7) | 3.9 (3.2 to 4.6) | |||
| AUC endothelium independent change in FBF | 31.7 (16.3 to 47.1) | 33.0 (14.1 to 51.9) | 26.7 (20.8 to 32.6) | 22.5 (17.4 to 27.6) | |||
| AUC endothelium dependent change in FBF | 48.8 (36.4 to 61.2) | 29.9 (18.0 to 41.1)1-151 | 34.6 (20.6 to 48.6) | 22.8 (12.0 to 33.6)1-151 | |||
| Difference in AUC from placebo (endothelium dependent) | 19 (4.0 to 34) | 13 (1.2 to 24) | |||||