Table 1

Heart rate and QT interval dynamics in control subjects, and patients with long QT syndrome types 1 (LQT1) and 2 (LQT2) at rest, and during mental stress and exercise

Heart rate (beats/min) QT interval (ms) ΔQT interval (ms) Change from
resting values (%)
ΔQT/ΔHR (ms/s) QTcf(ms) ΔQTcf (ms)
Control
 Rest59  (4)387  (16)384  (12)
 Mental stress90 (15)358 (22)1-168 –29  (25)1-160 7.4  (6.4)1-168 –0.96  (1.02)1-150 409 (25)1-165 24  (26)1-165
 Exercise stress93 (13)341 (25)1-168 –47 (31)1-160 11.7 (7.7)1-168 –1.33 (0.69)1-150 393 (21)1-165 9 (27)1-165
LQT1
 Rest64 (10)420 (35)426 (28)
 Mental stress98 (16)386 (33)–34 (34)9.1 (8.6)–1.21 (1.19)453 (35)27 (36)
 Exercise stress100 (14)382 (41)–38 (33)10.2 (8.74)–1.33 (1.27)451 (48)25 (42)
LQT2
 Rest59 (10)422 (40)419 (40)
 Mental stress91 (13)392 (40)–30 (51)6.4 (12.4)–0.71 (1.68)449 (37)30 (47)
 Exercise stress95 (13)383 (33)–38 (46)8.5 (10.9)–0.85 (1.37)445 (27)26 (42)
  • Values are mean (SD).

  • 1-150 p = 0.03,

  • 1-160 p = 0.04,

  • 1-165 p = 0.05,

  • 1-168 p = 0.005, all others not significant.

  • HR, heart rate; QTcf, QT interval adjusted according to Fridericia's formula.