Other conditions with glucocorticoid metabolite abnormalities
| Condition | Metabolic abnormality |
| Tumours | |
| Corticosterone secreting tumours | High concentrations of corticosterone |
| Deoxycorticosterone secreting tumours | High concentrations of deoxycorticosterone33 |
| Biosynthetic defects | |
| 17-Hydroxylase deficiency | High ratio of THF + αTHF/THE; low 17-hydroxycorticosterone concentrations34 |
| 11-Hydroxylase deficiency | Little or no cortisol excretion35 |
| Other conditions | |
| Cushing's disease | High serum cortisol levels; high excretion of urinary free cortisol36 |
| Mineralocorticoid excess syndrome | F:E ratio increased (cortisol to cortisone ratio increased)37 |
| Dexamethasone suppressible hyperaldosteronism | High urinary excretion of 18-hydroxycortisol metabolites38 |
| Partial glucocorticoid resistance | Total cortisol metabolites are increased |
F:E ratio, cortisol to cortisone ratio; THE, tetrahydrocortisone; THF, tetrahydrocortisol.