Haemodynamic effects of levosimendan
| Variable | Preischaemia (18 min after infusion) | Ischaemia (25 min) | Reperfusion (10 min) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Placebo | Levosimendan | Placebo | Levosimendan | Placebo | Levosimendan | ||||||
| Cardiac output (l/min) | 2.1 (0.3) | 2.5 (0.2)1-150 | 2.0 (0.2) | 2.6 (0.5)1-150 | 2.0 (0.1) | 2.6 (0.4)1-150 | |||||
| Heart rate (beats/min) | 80 (8) | 93 (23) | 92 (10) | 104 (21) | 96 (20) | 112 (17) | |||||
| Stroke volume (ml) | 28.3 (0.3) | 30.0 (0.25) | 21.0 (3.3) | 30.4 (1.5)1-151 | 21.5 (4.8) | 23.3 (4.4) | |||||
| Systemic vascular resistance (dyne.s−1.cm−5) | 2808 (209) | 2293 (348)1-150 | 2669 (424) | 2024 (188)1-151 | 2685 (66) | 2274 (293) | |||||
| Mean arterial pressure (mm Hg) | 70 (8) | 69 (7) | 66 (7) | 62 (9) | 68 (7) | 68 (11) | |||||
| LVmaxdP/dt (pos) (mm Hg/s) | 817 (129) | 972 (116)1-151 | 806 (151) | 925 (91)1-152 | 784 (130) | 956 (118)1-150 | |||||
| LVmaxdP/dt (neg) (mm Hg/s) | 1148 (240) | 1198 (254) | 1022 (162) | 945 (92) | 1110 (182) | 956 (282) | |||||
| LV peak systolic pressure (mm Hg) | 76 (11) | 75 (6) | 69 (7) | 71 (7) | 74 (10) | 74 (14) | |||||
| Rate–pressure product (mm Hg/min/kg) | 302 (22) | 317 (28) | 300 (18) | 338 (37) | 303 (15) | 345 (19) | |||||