Table 7

Angiotensin receptor blocker (ARB) trials in post-myocardial infarction patients: hypotheses tested

Non-inferioritySuperiority
ARB ⩽ ACE-IARB > ACE-IARB + ACE-I > ACE-I
OPTIMAALYes7-150 Yes7-151 ( 20%, P 96%)No
VALIANTYes ( 2.5%, P 88%) ( 0%, P 74%)Yes ( 17.5%, P 95%) ( 15%, P 86%)Yes ( 17.5%, P 95%) ( 15%, P 86%)
  • P, power—that is, power of study to detect that risk reduction.

  • ⩽, Not significantly inferior to;

  • 7-150 revision of protocol as publishedw27—further details not available;

  • 7-151 assuming a captopril group annual mortality of 17%.