Serial changes in biochemical and echocardiographic parameters
| 1 day before chemotherapy | 1 day after chemotherapy | 3 weeks after chemotherapy | Reference values | |
| Circulating concentrations | ||||
| BNP (pg/ml) | 13.7 (1.9) | 53.8 (3.5)1-150 | 12.6 (2.4) | < 20 |
| ANP (pg/ml) | 24.9 (4.5) | 30.3 (4.6) | 27.4 (3.9) | < 40 |
| Noradrenaline (pg/ml) | 277.1 (35.3) | 277.1 (33.8) | 257.9 (51.9) | 100–450 |
| Adrenaline (pg/ml) | 33.0 (6.0) | 32.4 (5.7) | 39.0 (12.8) | < 100 |
| Renin (resting supine) (ng/ml/h) | 1.37 (0.27) | 1.30 (0.23) | 1.09 (0.68) | 0.2–2.7 |
| Aldosterone (pm/ml) | 70.6 (8.2) | 69.2 (7.0) | 74.6 (16.0) | 45–105.5 |
| Echocardiographic parameters | ||||
| Fractional shortening (%) | 36.4 (1.0) | 36.0 (1.2) | 37.5 (0.9) | > 28 |
| Ejection fraction (%) | 72.9 (5.2) | 73.2 (6.3) | 72.4 (7.4) | > 56 |
| Mitral inflow E:A ratio | 1.45 (0.16) | 0.71 (0.24)1-150 | 1.29 (0.12) | > 1.0 |
| Deceleration time (ms) | 192.1 (9.9) | 271.3 (16.3)1-150 | 209.2 (13.6) | 199 (32) |
| Maximum diameter of IVC (mm) | 12.5 (1.8) | 12.9 (1.6) | 12.0 (2.0) | < 23 |
All data are expressed as mean (SEM).
Two way analysis of variance (ANOVA) and Fisher's exact test for post hoc analysis were carried out for multiple comparisons among groups.
↵1-150 p < 0.05 versus a day before chemotherapy.
ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; IVC, inferior vena cava.