Homozygosity at IL-1RN3-1502 illustrates the difference between single vessel disease (SVD) and multiple vessel disease (MVD) in the Leicester and Sheffield cohorts
| Alleles IL-1RN | ||||||
|---|---|---|---|---|---|---|
| SVD | MVD | |||||
| 11/12 3-150 | 22 3-151 | 11/12 3-150 | 22 3-151 | |||
| Leicester | ||||||
| Restenosis | 24 | 1 | 22 | 2 | ||
| Non-restenosis | 35 | 7 | 23 | 3 | ||
| p Value | 0.1573 | 0.7669 | ||||
| Odds ratio (95% CI) | 4.8 (0.6 to 41.6) | 1.4 (0.1 to 4.6) | ||||
| Sheffield | ||||||
| Restenosis | 16 | 0 | N/A | N/A | ||
| Non-restenosis | 25 | 7 | ||||
| p Value | 0.0384 | |||||
| Odds ratio (95% CI) | N/A | |||||
| MH p value | 0.0131 | |||||
↵3-150 11/12, raw numbers of 1,1 and 1,2 alleles at IL-1RN (VNTR). Allele 1 has four repeats and allele 2 has two repeats of 86 base pairs.
↵3-151 22, raw numbers of 2,2 homozygotes at IL-1RN (VNTR).
MH, Mantel–Haenszel summary statistic; N/A, odds ratio and p value not applicable as one of the values in the contingency table is 0.