Timing and haemodynamic response to dobutamine stress
| Variable | Controls (n=20) | Normal LV cavity (n=25) | Dilated LV cavity with restrictive filling (n=30) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| QRS < 120 ms (n=18) | QRS > 120 ms (n=12) | |||||||||||||
| Rest | Stress | Rest | Stress | Rest | Stress | Rest | Stress | |||||||
| Heart rate (beats/min) | 76 (8) | 128 (9)4-160 | 72 (13) | 126 (15)4-160 | 70 (14) | 119 (19)4-160 | 81 (13) | 119 (12)4-160 | ||||||
| QRS (ms) | 93 (7) | 85 (9)4-160 | 92 (13) | 105 (15)4-160 | 95 (13) | 100 (12)4-150 | 151 (15)4-162 | 153 (21) | ||||||
| ET (ms) | 270 (23) | 180 (20)4-160 | 264 (31) | 172 (20)4-160 | 257 (44) | 201 (26)4-160 | 209 (26)4-153 | 168 (21)4-160 | ||||||
| Long axis | ||||||||||||||
| q-OS (ms) | 81 (12) | 34 (5)4-160 | 108 (23)4-151 | 120 (17)4-150 | 118 (32) | 141 (43)4-160 | 140 (32)4-153 | 146 (19) | ||||||
| A2–OL (ms) | 56 (14) | 29 (9)4-160 | 89 (19)4-151 | 101 (17)4-160 | 83 (28) | 108 (26)4-160 | 113 (27)4-153 | 114 (30) | ||||||
| Haemodynamics | ||||||||||||||
| PAA (G) | 1.3 (0.3) | 3.5 (0.5)4-160 | 1.3 (0.4) | 2.9 (0.5)4-160 | 1.1 (0.3) | 1.9 (0.6)4-160 | 1.0 (0.2) | 1.6 (0.6)4-150 | ||||||
| Mitral E (m/s) | 0.7 (0.2) | 0.7 (0.2) | 0.7 (0.2) | 0.6 (0.2) | 0.9 (0.2)4-152 | 0.8 (0.3) | 1.0 (0.3) | 0.8 (0.3) | ||||||
| Mitral A (m/s) | 0.7 (0.2) | 0.9 (0.2)4-160 | 0.8 (0.2) | 1.0 (0.2)4-160 | 0.5 (0.2) | 0.7 (0.3)4-160 | 0.4 (0.4) | 0.5 (0.3)4-150 | ||||||
Values are mean (SD).
↵4-150 p < 0.01,
↵4-160 p < 0.001 stress versus rest within group (pairedt test);
↵4-151 p < 0.001 rest value normal cavity size versus rest value control (unpaired ttest);
↵4-152 : p<0.001 rest value DCM-NA versus rest value normal cavity (unpaired t test);
↵4-153 p < 0.01,
↵4-162 p < 0.001, rest value DCM-LBBB versus rest value DCM-NA (unpairedt test).
A, peak late diastolic inflow; E, peak early diastolic inflow; ET, time from onset of aortic flow to A2; PAA, peak aortic acceleration.