Model | Lesion inhibition (%) | |
Antiproliferative action | ||
Antisense oligodeoxynucleotide | ||
c-myb | Rat carotid | 84 |
c-myc | Porcine coronary | 70 |
PCNA | Rat carotid | 80 |
cyclin B | Rat carotid | 60 |
cyclin G1 | Rat carotid | 64 |
CDK-1 | Rat carotid | 40–47 |
CDK-2 | Rat carotid | 55–60 |
CDK-1 + CDK-2 | Rat carotid | 85 |
CDK-1 + PCNA | Rat carotid | 60 |
CDK-1 + cyclin B | Rat carotid | 78 |
Decoy oligodeoxynucleotide | ||
E2F | Rat carotid | 74 |
Gene transfer | ||
pRb (non-phosphorylatable) | Rat carotid Porcine femoral | 50 47 |
p130 | Rat carotid | 81 |
p21Cip1 | Rat carotid Porcine femoral | 46–58 37 |
p27Kip1 | Rat carotid | 49 |
p53 | Rabbit carotid | 85 |
GAX | Rabbit iliac | 56 |
ras (dominant negative) | Rat carotid | 62 |
Pro-apoptotic action | ||
Antisense oligodeoxynucleotide | ||
bcl-xL | Rabbit carotid | 561-150 |
Gene transfer | ||
Fas-ligand | Rat carotid | 60–73 |
Matrix action | ||
Gene transfer | ||
TIMP-1 | Rat carotid | 30 |
Pleiomorphic action | ||
Gene transfer | ||
eNOS | Rat carotid | 56–72 |
iNOS | Rat carotid | 95 |
Porcine iliac | 52 |
CDK, cyclin dependent kinase; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; GAX, growth arrest specific homeobox gene; pRb, retinoblastoma protein; PCNA, proliferating cell nuclear antigen;TIMP, tissue inhibitor of metalloproteinase.
↵1-150 Regression of previously formed lesion, as opposed to inhibition of lesion formation.