Genetics of hypertrophic cardiomyopathy (HCM)
| Mendelian dominance: variable penetrance |
| A disease of sarcomeric proteins |
| α and β myosin heavy chain |
| Troponin T and I |
| α Tropomyosin |
| Myosin binding protein C |
| α Cardiac actin |
| Myosin (essential and regulatory) light chain |
| Titin |
A genetically heterogeneous disease.
Mutations in the 10 listed sarcomeric proteins have been shown to account for the Mendelian dominant inheritance of HCM.