Doppler flow recordings during titration with metoprolol CR/XL
| Baseline | 2 weeks | 4 weeks | 6 weeks | 24 weeks | RM ANOVA | |
|---|---|---|---|---|---|---|
| Values are mean (SD). 95% confidence intervals are of differences versus baseline. | ||||||
| Metoprolol dose (mg) | 12.5 | 25 | 50 | 200 | ||
| Transmitral flow | ||||||
| E:A velocity ratio | 0.86 (0.39) | 0.9 (0.40) | 1.0 (0.43) | 1.09 (0.51) | 1.15 (0.78) | 0.009 |
| 95% CI | −0.15 to 0.05 | 0.04 to 0.22 | 0.11 to 0.34 | −0.08 to 0.67 | ||
| E deceleration time (ms) | 221 (61) | 210 (59) | 215 (88) | 221 (61) | 211 (73) | NS |
| 95% CI | −52 to 31 | −54 to 44 | −16 to 61 | −71 to 48 | ||
| Pulmonary venous flow | ||||||
| S peak velocity (m/s) | 0.51 (0.099) | 0.54 (0.063) | 0.53 (0.061) | 0.56 (0.079) | 0.54 (0.078) | NS |
| 95% CI | −0.062 to 0.12 | −0.040 to 0.023 | −0.020 to 0.12 | −0.022 to 0.13 | ||
| D peak velocity (m/s) | 0.42 (0.082) | 0.41 (0.080) | 0.42 (0.10) | 0.42 (0.084) | 0.43 (0.12) | NS |
| 95% CI | −0.060 to 0.071 | −0.047 to 0.092 | −0.034 to 0.071 | −0.086 to 0.084 | ||
| S:D velocity ratio | 1.26 (0.33) | 1.38 (0.35) | 1.35 (0.49) | 1.4 (0.34) | 1.39 (0.50) | NS |
| 95% CI | −0.17 to 0.37 | −0.27 to 0.24 | −0.13 to 0.33 | −0.26 to 0.68 | ||