The recognised markers of risk in HCM and their sensitivity, specificity, positive and negative predictive accuracy (PPA and NPA)
| Risk factor | Sensitivity (%) | Specificity (%) | PPA (%) | NPA (%) |
|---|---|---|---|---|
| *Figures provided are for the risk of death from all causes rather than sudden death only. | ||||
| †Figures provided are for risk of sudden death and/or appropriate ICD discharge. | ||||
| ‡In this data set from Elliott and colleagues, family history and syncope were combined in order to achieve statistical significance of relative risk. | ||||
| LVH, left ventricular hypertrophy; NSVT, non-sustained ventricular tachycardia; VF, ventricular fibrillation; VT, ventricular tachycardia. | ||||
| Abnormal blood pressure response: <40 years old19 | 75 | 66 | 15 | 97 |
| NSVT: adult <45 years old18 | 69 | 80 | 22 | 97 |
| NSVT: ≤21 years old23 | <10 | 89 | <10 | 85 |
| Inducible VT/VF: High risk populationw30 | 82 | 68 | 17 | 98 |
| *Syncope: <45 years old3 | 35 | 82 | 25 | 86 |
| *Family history: at least one unexplained sudden death ± HCM3 | 42 | 79 | 28 | 88 |
| †LVH ≥3 cm17 | 26 | 88 | 13 | 95 |
| †‡Two or more risk factors2 | 45 | 90 | 23 | 96 |