Effect of denervation on cardiac pharmacology
| Substance | Effect on recipient | Mechanism |
|---|---|---|
| AV, atrioventricular. | ||
| Digitalis | Normal increase of contractility; minimal effect on AV node | Direct myocardial effect; denervation |
| Atropine | None | Denervation |
| Adrenaline | Increased contractility; increased chronotropy | Denervation hypersensitivity |
| Noradrenaline | Increased contractility; increased chronotropy | Denervation hypersensitivity |
| Isoproterenol | Normal increase in contractility; normal increase in chronotropy | No neuronal uptake |
| Quinidine | No vagolytic effect | Denervation |
| Verapamil | AV block | Direct effect |
| Nifedipine | No reflex tachycardia | Denervation |
| Hydralazine | No reflex tachycardia | Denervation |
| β Blocker | Increased antagonist effect | Denervation |