Genotype distribution of the GPIba VNTR and Kozak polymorphisms between the infarct and non-infarct patient groups
| VNTR | Kozak | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| AC | BC | BD | CC | CD | DD | TT* | TC | CC | |
| Values are n (%). | |||||||||
| No significant association was found between the VNTR genotypes and myocardial infarction (p=0.60). Considering the CC genotype v all other VNTR genotypes, there was a marginal association (p=0.059, OR 1.8, 95% CI 0.94 to 3.48). | |||||||||
| *A significant association was found between the Kozak TT genotype and myocardial infarction (p<0.001, OR 2.10, 95% CI 1.11 to 4.02); the TT v TC+CC Kozak genotype also showed a significant association with myocardial infarction (p=0.002, OR 2.81, 95% CI 1.37 to 5.82). | |||||||||
| CI, confidence interval; OR, odds ratio; VNTR, variable number tandem repeat. | |||||||||
| Infarct group (n=88) | 0 (0.0) | 6 (6.8) | 3 (3.4) | 69 (78.4) | 8 (9.1) | 2 (2.3) | 75 (85.2) | 11 (12.5) | 2 (2.3) |
| Non-infarct group (n=168) | 1 (0.6) | 23 (13.6) | 2 (1.2) | 113 (67.3) | 27 (16.1) | 2 (1.2) | 113 (67.3) | 55 (32.7) | 0 (0.0) |