Exercise ECG data for the four exercise tests
| Placebo 1 | Placebo 2 | Drug 1 | Drug 2 | p Value | |
|---|---|---|---|---|---|
| Values are mean (SD). | |||||
| Comparisons between all four exercise tests using two way parametric analysis of variance; pairwise comparisons using Student's t test for paired data with Bonferroni correction. | |||||
| *p<0.05 v placebo 1; †p<0.05 v drug 1. | |||||
| RPP, rate–pressure product; SBP, systolic blood pressure. | |||||
| Baseline | |||||
| Heart rate (beats/min) | 65 (2) | 66 (2) | 65 (3) | 68 (2) | NS |
| SBP (mm Hg) | 155 (4) | 151 (5) | 160 (4) | 154 (4) | 0.01 |
| RPP (×103 mm Hg/min) | 10.1 (2.0) | 9.9 (1.9) | 10.5 (2.5) | 10.5 (2.4) | NS |
| ST depression (mm) | −0.1 (0.1) | −0.1 (0.1) | −0.1 (0.1) | −0.1 (0.1) | NS |
| Chest pain onset | |||||
| Time (min) | 5.9 (0.7) | 6.8 (0.7)* | 6.5 (0.6) | 7.2 (0.6)† | 0.03 |
| Heart rate (beats/min) | 98 (4) | 103 (4)* | 96 (3) | 100 (3)† | 0.02 |
| SBP (mm Hg) | 168 (4) | 173 (6) | 177 (5) | 174 (4) | NS |
| RPP (×103 mm Hg/min) | 16.6 (2.9) | 17.8 (3.6) | 17.1 (3.5) | 17.5 (3.0) | NS |
| ST depression (mm) | 1.3 (0.3) | 1.1 (0.3) | 1.3 (0.3) | 1.2 (0.3) | NS |
| 1 mm ST depression | |||||
| Time (min) | 6.0 (0.8) | 6.9 (0.8)* | 6.5 (0.8) | 7.2 (0.8)† | 0.009 |
| Heart rate (beats/min) | 99 (4) | 105 (4)* | 98 (4) | 105 (5)† | <0.0001 |
| SBP (mm Hg) | 171 (5) | 177 (6) | 177 (5) | 178 (4) | NS |
| RPP (×103 mm Hg/min) | 17.0 (3.7) | 18.6 (4.3)* | 17.5 (4.0) | 18.8 (4.3)† | 0.003 |
| Peak exercise | |||||
| Time (min) | 8.9 (0.6) | 9.1 (0.6) | 9.2 (0.7) | 9.4 (0.7) | NS |
| Heart rate (beats/min) | 107 (3) | 110 (4)* | 107 (4) | 110 (4)† | 0.03 |
| SBP (mm Hg) | 187 (5) | 185 (5) | 190 (4) | 185 (4) | NS |
| RPP (×103 mm Hg/min) | 20.0 (4.0) | 20.3 (4.6) | 20.4 (4.4) | 20.5 (4.8) | NS |
| ST depression (mm) | 1.7 (0.3) | 1.5 (0.3) | 1.6 (0.2) | 1.5 (0.3) | NS |